Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of 2-Picolinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 2/20 | 0.44 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.61 |
| ▸ | CES1 | P23141 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.59 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Picolinic Acid SCHEMBL6653226 | 0.98 | CES2 (0.64) | CES2CES1L3MBTL1LMNAP4HTM | |
| 2-Picolinic Acid SCHEMBL31146764 | 0.98 | CES2 (0.64) | CES2CES1L3MBTL1LMNAP4HTM | |
| 2-Picolinic Acid SCHEMBL30123760 | 0.98 | CES2 (0.64) | CES2CES1L3MBTL1LMNAP4HTM | |
| 2-Picolinic Acid SCHEMBL1711528 | 0.98 | CES2 (0.64) | CES2CES1L3MBTL1LMNAP4HTM | |
| 2-Picolinic Acid SCHEMBL30616634 | 0.96 | CES2 (0.61) | CES2CES1L3MBTL1LMNAP4HTM | |
| 2-Picolinic Acid SCHEMBL9135848 | 0.96 | CES2 (0.61) | CES2CES1L3MBTL1LMNAP4HTM | |
| 2-Picolinic Acid SCHEMBL11378795 | 0.96 | CES2 (0.67) | CES2CES1L3MBTL1LMNAP4HTM | |
| 2-Picolinic Acid SCHEMBL673572 | 0.93 | CES2 (0.64) | CES2CES1L3MBTL1LMNAP4HTM | |
| 2-Picolinic Acid SCHEMBL5354659 | 0.93 | CES2 (0.64) | CES2CES1L3MBTL1LMNAP4HTM | |
| 2-Picolinic Acid SCHEMBL432468 | 0.93 | CES2 (0.64) | CES2CES1L3MBTL1LMNAP4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116581349-A | Organic water phase salt cavern symmetrical flow battery based on bipyridine metal cobalt complex | 中盐金坛盐化有限责任公司 | 2023-08-11 | — | — | CN | disclosed |