Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of 2-Picolinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 2/20 | 0.45 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.64 |
| ▸ | CES1 | P23141 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.61 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Picolinic Acid SCHEMBL30123760 | 1.00 | CES2 (0.64) | CES2CES1L3MBTL1LMNAP4HTM | |
| 2-Picolinic Acid SCHEMBL30616633 | 0.98 | CES2 (0.61) | CES2CES1L3MBTL1LMNAP4HTM | |
| 2-Picolinic Acid SCHEMBL11378795 | 0.98 | CES2 (0.67) | CES2CES1L3MBTL1LMNAP4HTM | |
| 2-Picolinic Acid SCHEMBL1462619 | 0.95 | CES2 (0.64) | CES2CES1L3MBTL1LMNAP4HTM | |
| 2-Picolinic Acid SCHEMBL5058098 | 0.95 | CES2 (0.64) | CES2CES1L3MBTL1LMNAP4HTM | |
| 2-Picolinic Acid SCHEMBL524041 | 0.95 | CES2 (0.64) | CES2CES1L3MBTL1LMNAP4HTM | |
| 2-Picolinic Acid SCHEMBL673572 | 0.95 | CES2 (0.64) | CES2CES1L3MBTL1LMNAP4HTM | |
| 2-Picolinic Acid SCHEMBL5354659 | 0.95 | CES2 (0.64) | CES2CES1L3MBTL1LMNAP4HTM | |
| 2-Picolinic Acid SCHEMBL15401421 | 0.95 | CES2 (0.64) | CES2CES1L3MBTL1LMNAP4HTM | |
| 2-Picolinic Acid SCHEMBL11378797 | 0.95 | CES2 (0.64) | CES2CES1L3MBTL1LMNAP4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 127 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119317438-A | Polyion complexes for preventing or treating inflammation | 伊尼奥斯制药公司 | 2025-01-14 | — | — | CN | claimed |
| US-20240075043-A1 | IMMEDIATE AND CONTROLLED RELEASE APPETITE SUPPRESSANT COMPOSITIONS FOR WEIGHT LOSS | Red Mountain Med Spa, LLC (US) | 2024-03-07 | — | — | US | claimed |
| CN-116539389-A | Water-soluble trace element tracer and preparation method and application thereof | 大庆信辰油田技术服务有限公司 | 2023-08-04 | — | — | CN | claimed |
| US-20220249505-A1 | APPETITE SUPPRESSANT COMPOSITIONS AND METHODS THEREOF | RED MOUNTAIN HOLDINGS, LLC (US) | 2022-08-11 | — | — | US | claimed |
| US-20210275536-A1 | APPETITE SUPPRESSANT COMPOSITIONS AND METHODS THEREOF | RED MOUNTAIN HOLDINGS, LLC (US) | 2021-09-09 | — | — | US | claimed |
| CN-110755622-A | Use of inhibitors of phosphatase and tensin homologues for the manufacture of a medicament | 同济大学 | 2020-02-07 | — | — | CN | claimed |
| US-20130273199-A1 | BEVERAGE AND METHOD FOR PRODUCING A SPARKLING BEVERAGE WHICH IS A NUTRITIOUS ALTERNATIVE TO MILK WITH ALL THE NUTRITION OF MILK PLUS ANTRHOCYANINS | CLARK GEORGE H (US) | 2013-10-17 | — | — | US | claimed |
| EP-1238977-B2 | PROCESS FOR THE PREPARATION OF A PYRIDINEMETHANOL COMPOUND | SUMITOMO CHEMICAL CO (JP) | 2010-07-21 | — | — | EP | claimed |
| EP-1599099-A4 | CARBONATED FORTIFIED MILK-BASED BEVERAGE AND METHOD FOR SUPPRESSING BACTERIAL GROWTH IN THE BEVERAGE | MAC FARMS INC (US) | 2006-05-24 | — | — | EP | claimed |
| EP-1599099-A1 | CARBONATED FORTIFIED MILK-BASED BEVERAGE AND METHOD FOR SUPPRESSING BACTERIAL GROWTH IN THE BEVERAGE | Mac Farms, Inc. (US) | 2005-11-30 | — | — | EP | claimed |
| US-6835402-B1 | 10-344 ml of water, 1-1000 g of non-fat dry milk, .01-119 meq of calcium ions, .01-60 meq of magnesium ions, .01-50 meq of potassium ions, .01-1000 g of a sweetener and .1-4 volumes of carbon dioxide gas | MAC FARMS INC. | 2004-12-28 | — | — | US | claimed |
| WO-2004068957-A1 | CARBONATED FORTIFIED MILK-BASED BEVERAGE AND METHOD FOR SUPPRESSING BACTERIAL GROWTH IN THE BEVERAGE | MAC FARMS, INC. (US) | 2004-08-19 | — | — | WO | claimed |
| US-20030228347-A1 | Amino acid chelate for the effective supplementation of calcium magnesium and potassium in the human diet | PARSONS, RONALD O. | 2003-12-11 | — | — | US | claimed |
| EP-1238977-B1 | PROCESS FOR THE PREPARATION OF A PYRIDINEMETHANOL COMPOUND | SUMIKA FINE CHEMICALS CO LTD (JP) | 2003-11-26 | — | — | EP | claimed |
| US-6582722-B1 | chelates for enhancing the absorption and assimilation of essential minerals in the human diet. Calcium, magnesium and potassium picolinic acid salts are disclosed as food and beverage supplements to improve the nutritive capacity of | MAC FARMS, INC. | 2003-06-24 | — | — | US | claimed |
| US-20030113408-A1 | Carbonated fortified milk-based beverage and method for suppressing bacterial growth in the beverage | PARSONS, RONALD O. | 2003-06-19 | — | — | US | claimed |
| EP-1238977-A1 | PROCESS FOR THE PREPARATION OF A PYRIDINEMETHANOL COMPOUND | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2002-09-11 | — | — | EP | claimed |
| US-6403129-B1 | WATER; NONFAT DRY MILK; CALCIUM, MAGNESIUM AND POTASSIUM SALTS; | MAC FARMS, INC. | 2002-06-11 | — | — | US | claimed |
| US-6376668-B1 | REACTING PYRIDINECARBONITRILE COMPOUND WITH POTASSIUM HYDROXIDE IN BUTANOL; HYDROLYSIS | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2002-04-23 | — | — | US | claimed |
| US-20020035255-A1 | Process for preparing pyridinemethanol compounds | SUMIKA FINE CHEMICALS CO., LTD. | 2002-03-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020035255-A1 | Process for preparing pyridinemethanol compounds | TPH1, KCNMA1, KCNT1 | PTGS2 1617/4885PTGS1 953/4885CES2 2056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.