Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14749252 | 0.83 | MAPT (0.38) | MAPTKDM4ENOTUMHTTHTR1A | |
| SCHEMBL885485 | 0.83 | NOTUM (0.49) | MAPTKDM4ENOTUMHTTHTR1A | |
| SCHEMBL2308270 | 0.82 | ALDH1A1 (0.39) | MAPTKDM4ENOTUMHTTHTR1A | |
| SCHEMBL420546 | 0.81 | L3MBTL1 (0.43) | MAPTKDM4ENOTUMHTTHTR1A | |
| SCHEMBL13485763 | 0.79 | KDM4E (0.42) | MAPTKDM4EBRCA1HSD17B10SCD | |
| SCHEMBL2305192 | 0.79 | MAPT (0.42) | MAPTKDM4EBRCA1HSD17B10SCD | |
| SCHEMBL13753406 | 0.78 | NPSR1 (0.43) | MAPTKDM4EHTTHSD17B10AURKA | |
| SCHEMBL2280370 | 0.76 | GAA (0.54) | MAPTKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL13753597 | 0.76 | POLB (0.44) | MAPTKDM4ESCDAURKARPS6KB1 | |
| SCHEMBL13753489 | 0.76 | TAS1R3 (0.40) | MAPTKDM4EHTTBRCA1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221814-B2 | Heterocyclic guanidine F1F0-atpase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-12-29 | — | — | US | disclosed |
| US-9221814-B2 | Heterocyclic guanidine F1F0-atpase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-12-29 | — | — | US | disclosed |
| US-9221814-B2 | Heterocyclic guanidine F1F0-atpase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-12-29 | — | — | US | disclosed |
| US-20150148373-A1 | HETEROCYCLIC GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2015-05-28 | — | — | US | disclosed |
| US-20150148373-A1 | HETEROCYCLIC GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2015-05-28 | — | — | US | disclosed |
| US-20150148373-A1 | HETEROCYCLIC GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2015-05-28 | — | — | US | disclosed |
| EP-2866893-A2 | HETEROCYCLIC GUANIDINE F1F0-ATPASE INHIBITORS | Lycera Corporation (US) | 2015-05-06 | — | — | EP | disclosed |
| US-8785662-B2 | Anilide-based compounds for preserving wood and method of use thereof | SDS BIOTECH K.K. (JP) | 2014-07-22 | — | — | US | disclosed |
| WO-2013185048-A2 | HETEROCYCLIC GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2013-12-12 | — | — | WO | disclosed |
| US-8541406-B2 | Thiadiazole derivatives for the treatment of neurodegenerative diseases | NV REMYND (BE) | 2013-09-24 | — | — | US | disclosed |
| US-20130059014-A1 | PRESERVATIVE FOR PRESERVING WOOD AND METHOD FOR TREATING WOOD | SDS BIOTECH K. K. (JP) | 2013-03-07 | — | — | US | disclosed |
| US-20100261707-A9 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2010-10-14 | — | — | US | disclosed |
| US-20090233911-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-09-17 | — | — | US | disclosed |
| US-20090054410-A1 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-26 | — | — | US | disclosed |
| US-20060293297-A1 | Cyanofluoropyrrolidine derviative | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2006-12-28 | — | — | US | disclosed |
| CN-1791575-A | Cyanofluoropyrrolidine derivative. | TAISHO PHARMACEUTICAL CO LTD (JP) | 2006-06-21 | — | — | CN | disclosed |
| EP-1627870-A1 | CYANOFLUOROPYRROLIDINE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2006-02-22 | — | — | EP | disclosed |
| CN-1091349-C | N-(heterocycloformyl) sulfonamide herbicide | SHENYANG INST OF CHEMICAL ENGI (CN) | 2002-09-25 | — | — | CN | disclosed |
| CN-1274528-A | N-(heterocycloformyl) sulfonamide herbicide | SHENYANG INST OF CHEMICAL ENGI (CN) | 2000-11-29 | — | — | CN | disclosed |
| US-6117821-A | COMPRISING HERBICIDES AND AGRONOMICALLY ACCEPTABLE CARRIERS; USE THEREOF AS BROAD SPECTRUM HERBICIDES WHICH ARE EFFECTIVE AGAINST BOTH MONOCOT AND DICOT WEED SPECIES IN BOTH PREEMERGENCE AND POSTEMERGENCE APPLICATIONS | ROHM AND HAAS COMPANY (US) | 2000-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150148373-A1 | HETEROCYCLIC GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | ATP5F1A, ATP5ME, ATP5F1D | MAPT 3486/4885KDM4E 1801/4885NOTUM 4498/4885 |
| US-20090233911-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, HTT, PARK7 | MAPT 9/4885KDM4E 4164/4885NOTUM 4364/4885 |
| US-20130059014-A1 | PRESERVATIVE FOR PRESERVING WOOD AND METHOD FOR TREATING WOOD | ALKBH5, DCXR, AKR7A2 | MAPT 1158/4885KDM4E 44/4885NOTUM 143/4885 |
| US-20060293297-A1 | Cyanofluoropyrrolidine derviative | DPP4, DPP3, NPY4R | MAPT 4708/4885KDM4E 1464/4885NOTUM 2375/4885 |
| US-20100261707-A9 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, HTT, PARK7 | MAPT 9/4885KDM4E 4164/4885NOTUM 4364/4885 |
| US-20090054410-A1 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, HTT, PARK7 | MAPT 9/4885KDM4E 4164/4885NOTUM 4364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.