Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SI | P14410 | 1/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3064787 | 1.00 | MGAM (0.48) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL1895727 | 1.00 | MGAM (0.48) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL1258369 | 0.88 | GAA (0.55) | MGAMGAASIMGAM2ALDH1A1 | |
| Glycerin SCHEMBL28329026 | 0.85 | MGAM (0.43) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL1427228 | 0.84 | MGAM (0.50) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL9743315 | 0.84 | MGAM (0.50) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL3853840 | 0.84 | MGAM (0.50) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL7194339 | 0.83 | MGAM (0.44) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL5453913 | 0.82 | MGAM (0.48) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL27749970 | 0.81 | LMNA (0.38) | ALDH1A1LMNAKMT2AKDM4EDUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261251-A1 | MICROBIAL KINETIC RESOLUTION OF ETHYL-3,4-EPOXYBUTYRATE | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2010-10-14 | — | — | US | claimed |
| CN-101821404-A | Microbial kinetic resolution of ethyl 3, 4-epoxybutyrate | AGENCY SCIENCE TECH & RES | 2010-09-01 | — | — | CN | claimed |
| EP-2179050-A1 | MICROBIAL KINETIC RESOLUTION OF ETHYL-3,4-EPOXYBUTYRATE | Agency for Science, Technology And Research (SG) | 2010-04-28 | — | — | EP | claimed |
| WO-2009008834-A1 | MICROBIAL KINETIC RESOLUTION OF ETHYL-3,4-EPOXYBUTYRATE | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2009-01-15 | — | — | WO | claimed |
| CN-116904530-A | Biological preparation method of atorvastatin calcium intermediate | 江苏福瑞康泰药业有限公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-115894290-A | Preparation method of atorvastatin calcium intermediate (R) - (-) -4-cyano-3-hydroxy ethyl butyrate | 宿迁阿尔法科技有限公司 | 2023-04-04 | — | — | CN | disclosed |
| US-20220098191-A1 | G-A CROSSLINKING CYTOTOXIC AGENTS | Pheon Therapeutics Ltd. (GB) | 2022-03-31 | — | — | US | disclosed |
| EP-2462111-B1 | PREPARATION OF (R)- AND (S)-N-(3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)-6-METHOXYPHENYL)-1-(2,3-DIHYDROXYPROPYL)CYCLOPROPANE-1-SULFONAMIDE AND PROTECTED DERIVATIVES THEREOF | ARDEA BIOSCIENCES INC (US) | 2016-03-30 | — | — | EP | disclosed |
| US-8884058-B2 | Preparation of (R)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and (S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide | ARDEA BIOSCIENCES (US) | 2014-11-11 | — | — | US | disclosed |
| US-8884058-B2 | Preparation of (R)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and (S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide | ARDEA BIOSCIENCES (US) | 2014-11-11 | — | — | US | disclosed |
| CN-102295579-B | Synthesis process for (R)-4-cyano-3-hydroxybutyric acid ethyl ester | ANQING JINQUAN PHARM CO LTD | 2014-05-21 | — | — | CN | disclosed |
| US-20130261320-A1 | PREPARATION OF (R)-N-(3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)-6-METHOXYPHENYL)-1-(2,3-DIHYDROXYPROPYL)CYCLOPROPANE-1-SULFONAMIDE AND (S)- N-(3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)-6-METHOXYPHENYL)-1-(2,3-DIHYDROXYPROPYL)CYCLOPROPANE-1-SULFONAMIDE | ARDEA BIOSCIENCES, INC. (US) | 2013-10-03 | — | — | US | disclosed |
| US-20100261251-A1 | MICROBIAL KINETIC RESOLUTION OF ETHYL-3,4-EPOXYBUTYRATE | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2010-10-14 | — | — | US | disclosed |
| US-20100261251-A1 | MICROBIAL KINETIC RESOLUTION OF ETHYL-3,4-EPOXYBUTYRATE | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2010-10-14 | — | — | US | disclosed |
| CN-101821404-A | Microbial kinetic resolution of ethyl 3, 4-epoxybutyrate | AGENCY SCIENCE TECH & RES | 2010-09-01 | — | — | CN | disclosed |
| EP-2179050-A1 | MICROBIAL KINETIC RESOLUTION OF ETHYL-3,4-EPOXYBUTYRATE | Agency for Science, Technology And Research (SG) | 2010-04-28 | — | — | EP | disclosed |
| US-20090054452-A1 | Thienopyridine Derivatives and the Use Thereof as Hsp90 Modulators | MERCK PATENT GMBH (DE) | 2009-02-26 | — | — | US | disclosed |
| US-20090054452-A1 | Thienopyridine Derivatives and the Use Thereof as Hsp90 Modulators | MERCK PATENT GMBH (DE) | 2009-02-26 | — | — | US | disclosed |
| WO-2009008834-A1 | MICROBIAL KINETIC RESOLUTION OF ETHYL-3,4-EPOXYBUTYRATE | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2009-01-15 | — | — | WO | disclosed |
| WO-2009008834-A1 | MICROBIAL KINETIC RESOLUTION OF ETHYL-3,4-EPOXYBUTYRATE | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2009-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054452-A1 | Thienopyridine Derivatives and the Use Thereof as Hsp90 Modulators | HSP90AA1, HSP90AB1, HSP90AB2P | MGAM 4638/4885GAA 2393/4885SI 4847/4885 |
| US-20220098191-A1 | G-A CROSSLINKING CYTOTOXIC AGENTS | CCNA1, GNA15, RPS26 | MGAM 4497/4885GAA 3482/4885SI 4565/4885 |
| US-20130261320-A1 | PREPARATION OF (R)-N-(3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)-6-METHOXYPHENYL)-1-(2,3-DIHYDROXYPROPYL)CYCLOPROPANE-1-SULFONAMIDE AND (S)- N-(3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)-6-METHOXYPHENYL)-1-(2,3-DIHYDROXYPROPYL)CYCLOPROPANE-1-SULFONAMIDE | DHPS, SULT2A1, S1PR2 | MGAM 4709/4885GAA 4459/4885SI 892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.