Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2284498 | 0.98 | KIF11 (0.42) | KIF11ENPP2TAAR1ESR1ESR2 | |
| SCHEMBL3978037 | 0.78 | TAAR1 (0.57) | KIF11ENPP2TAAR1ESR1ESR2 | |
| SCHEMBL27715400 | 0.77 | KIF11 (0.46) | KIF11ENPP2ESR1ESR2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5800348 | 0.77 | TAAR1 (0.55) | KIF11ENPP2TAAR1ESR1ESR2 | |
| SCHEMBL31441290 | 0.77 | ESR1 (0.41) | KIF11ESR1ESR2ALDH1A1CYP3A4 | |
| SCHEMBL1767723 | 0.77 | ESR1 (0.41) | KIF11ESR1ESR2ALDH1A1CYP3A4 | |
| SCHEMBL13930904 | 0.76 | ESR1 (0.44) | KIF11ESR1ESR2ALDH1A1CYP3A4 | |
| SCHEMBL31215161 | 0.76 | LMNA (0.44) | KIF11ESR1ESR2ALDH1A1CYP3A4 | |
| SCHEMBL825377 | 0.76 | LMNA (0.44) | KIF11ESR1ESR2ALDH1A1CYP3A4 | |
| SCHEMBL11783483 | 0.76 | ALDH1A1 (0.44) | KIF11ESR1ESR2ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11007156-B2 | Prolonged release pharmaceutical composition containing 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol | GRUENENTHAL GMBH (DE) | 2021-05-18 | — | — | US | claimed |
| US-20200038344-A1 | PROLONGED RELEASE PHARMACEUTICAL COMPOSITION CONTAINING 3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)PHENOL | GRUENENTHAL GMBH (DE) | 2020-02-06 | — | — | US | claimed |
| EP-2046724-B1 | PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL | GRUENENTHAL GMBH (DE) | 2014-08-20 | — | — | EP | claimed |
| US-11007156-B2 | Prolonged release pharmaceutical composition containing 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol | GRUENENTHAL GMBH (DE) | 2021-05-18 | — | — | US | disclosed |
| US-20200276188-A1 | TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION | Grünenthal GmbH (DE) | 2020-09-03 | — | — | US | disclosed |
| US-10632195-B2 | Pharmaceutical device for electric-field assisted administration of Tapentadol and method of administering Tapentadol with same | GRUENENTHAL GMBH (DE) | 2020-04-28 | — | — | US | disclosed |
| US-20200038344-A1 | PROLONGED RELEASE PHARMACEUTICAL COMPOSITION CONTAINING 3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)PHENOL | GRUENENTHAL GMBH (DE) | 2020-02-06 | — | — | US | disclosed |
| US-20200030317-A1 | TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION | Grünenthal GmbH (DE) | 2020-01-30 | — | — | US | disclosed |
| US-20180369237-A1 | Tamper-resistant dosage form with immediate release and resistance against solvent extraction | Grünenthal GmbH (DE) | 2018-12-27 | — | — | US | disclosed |
| US-20180078544-A1 | TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION | Grünenthal GmbH (DE) | 2018-03-22 | — | — | US | disclosed |
| US-20170112766-A1 | TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION | Grünenthal GmbH (DE) | 2017-04-27 | — | — | US | disclosed |
| EP-2424514-B1 | TAPENTADOL FOR TREATING RHEUMATOID ARTHRITIC PAIN | GRUENENTHAL GMBH (DE) | 2017-02-22 | — | — | EP | disclosed |
| US-9394250-B2 | Substituted pyrrolidines as factor xia inhibitors for the treatment thromboembolic diseases | ONO PHARMACEUTICAL CO., LTD. (JP) | 2016-07-19 | — | — | US | disclosed |
| US-20150148735-A1 | Electric-Field Assisted Administration of Tapentadol | GRUENENTHAL GMBH (DE) | 2015-05-28 | — | — | US | disclosed |
| US-20100227921-A1 | AMINO ACID AND PEPTIDE CARBAMATE PRODRUGS OF TAPENTADOL AND USES THEREOF | SHIRE LLC (US) | 2010-09-09 | — | — | US | disclosed |
| EP-1985292-A1 | Titration of tapentadol | Grünenthal GmbH (DE) | 2008-10-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150148735-A1 | Electric-Field Assisted Administration of Tapentadol | SLC1A1, SLC6A2, SLC9A3 | KIF11 2892/4885ENPP2 1721/4885TAAR1 177/4885 |
| US-10632195-B2 | Pharmaceutical device for electric-field assisted administration of Tapentadol and method of administering Tapentadol with same | SLC6A2, SLC9A2, ATP1A2 | KIF11 2875/4885ENPP2 2118/4885TAAR1 190/4885 |
| US-20100227921-A1 | AMINO ACID AND PEPTIDE CARBAMATE PRODRUGS OF TAPENTADOL AND USES THEREOF | VIP, DNPEP, PEPD | KIF11 3965/4885ENPP2 2573/4885TAAR1 973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.