SCHEMBL3067730

SCHEMBL3067730

CC(C)(C)NC(=S)Nc1ccccc1

nearest known ligand 0.86

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 5/20 0.86
KMT2A Q03164 5/20 0.86
MAPT P10636 4/20 0.86
ALDH1A1 P00352 3/20 0.86
SMN1; SMN2 Q16637 3/20 0.86
MEN1 O00255 3/20 0.86
CYP1A2 P05177 3/20 0.86
CYP2C19 P33261 3/20 0.86
CYP3A4 P08684 2/20 0.86
CYP2C9 P11712 2/20 0.86
CYP2D6 P10635 1/20 0.86
HPGD P15428 1/20 0.86
ALOX12 P18054 1/20 0.86
L3MBTL1 Q9Y468 1/20 0.86
HTT P42858 1/20 0.67
TAS2R38 P59533 2/20 0.64
HSD17B10 Q99714 1/20 0.64
RAB9A P51151 3/20 0.59
NPC1 O15118 2/20 0.59
NOX1 Q9Y5S8 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11326932 0.81 GAA (0.60) GAAKMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL19891237 0.81 GAA (0.60) GAAKMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL3041278 0.81 POLB (0.61) GAAKMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL19891235 0.81 ALDH1A1 (0.60) GAAKMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL19891238 0.81 GAA (0.60) GAAKMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL24534286 0.80 HTT (0.68) GAAKMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL17465537 0.80 HTT (0.68) GAAKMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL19891039 0.80 HTT (0.68) GAAKMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL19891157 0.80 ALDH1A1 (0.58) GAAKMT2AMAPTALDH1A1SMN1; SMN2
SCHEMBL15946364 0.79 ALDH1A1 (0.63) GAAKMT2AMAPTALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115449136-A Accelerator composition of rubber nanocomposite and preparation method and application thereof 浙江大学 2022-12-09 CN claimed
CN-115449136-B Accelerator composition of rubber nanocomposite as well as preparation method and application thereof 浙江大学 2024-02-27 CN disclosed
CN-115449136-A Accelerator composition of rubber nanocomposite and preparation method and application thereof 浙江大学 2022-12-09 CN disclosed
US-20200071316-A1 ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE \"RIG-I\" PATHWAY AND METHODS OF USE THEREOF Kineta Immuno-Oncology LLC 2020-03-05 US disclosed
US-10253256-B2 Use of sulfur and selenium compounds as precursors to nanostructured materials THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2019-04-09 US disclosed
WO-2018035291-A1 1,2,4-TRIAZOLIDINE-3-THIONE DERIVATIVES AND USES THEREOF NORTH CAROLINA STATE UNIVERSITY (US) 2018-02-22 WO disclosed
US-9464064-B2 HCV helicase inhibitors and methods of use thereof UNIVERSITY OF KANSAS (US) 2016-10-11 US disclosed
US-20160237345-A1 USE OF SULFUR AND SELENIUM COMPOUNDS AS PRECURSORS TO NANOSTRUCTURED MATERIALS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2016-08-18 US disclosed
EP-3049370-A1 USE OF SULFUR AND SELENIUM COMPOUNDS AS PRECURSORS TO NANOSTRUCTURED MATERIALS The Trustees of Columbia University in the City of New York (US) 2016-08-03 EP disclosed
US-8907091-B2 Processes and intermediates for preparing fused heterocyclic kinase inhibitors METHYLGENE INC. (CA) 2014-12-09 US disclosed
EP-1811342-B1 USE OF A SULFUR-ATOM-CONTAINING COMPOSITION FOR FORMING OF LITHOGRAPHIC ANTIREFLECTION FILM NISSAN CHEMICAL IND LTD (JP) 2013-07-10 EP disclosed
US-7795369-B2 Sulfur atom-containing anti-reflective coating forming composition for lithography NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2010-09-14 US disclosed
US-20090286984-A1 Processes and intermediates for preparing fused heterocyclic kinase inhibitors Mirati Therapeutics, Inc. 2009-11-19 US disclosed
US-7557110-B2 MAPKAP-K2; inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth; 5-[(trans-4-aminocyclohexyl)amino]-3-fluoro-6-methyl(pyrazolo[1,5-a]pyri- midin-7-yl)}(4-iodophenyl)amine TEIJIN PHARMA LIMITED (JP) 2009-07-07 US disclosed
US-7557110-B2 MAPKAP-K2; inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth; 5-[(trans-4-aminocyclohexyl)amino]-3-fluoro-6-methyl(pyrazolo[1,5-a]pyri- midin-7-yl)}(4-iodophenyl)amine TEIJIN PHARMA LIMITED (JP) 2009-07-07 US disclosed
US-20080118870-A1 Sulfur Atom-Containing Anti-Reflective Coating Forming Composition For Lithography NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2008-05-22 US disclosed
EP-1811342-A1 SULFUR-ATOM-CONTAINING COMPOSITION FOR FORMING OF LITHOGRAPHIC ANTIREFLECTION FILM Nissan Chemical Industries, Ltd. (JP) 2007-07-25 EP disclosed
US-20070040151-A1 Two-component initiator system (amine-free) with very good storage stability and particular suitability for acid systems HERAEUS KULZER GMBH (DE) 2007-02-22 US disclosed
US-4990232-A Photooxidation of N,N*-substituted thiourea CIBA-GEIGY CORPORATION (US) 1991-02-05 US disclosed
US-4159328-A INSECTICIDES, MITICIDES NIHON NOHYAKU CO., LTD. (JP) 1979-06-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090286984-A1 Processes and intermediates for preparing fused heterocyclic kinase inhibitors MAP3K19, MAP3K9, MAP4K2 GAA 2409/4885KMT2A 938/4885MAPT 1952/4885
US-10253256-B2 Use of sulfur and selenium compounds as precursors to nanostructured materials SCLY, TST, SOD1 GAA 1399/4885KMT2A 4073/4885MAPT 601/4885
US-20080118870-A1 Sulfur Atom-Containing Anti-Reflective Coating Forming Composition For Lithography TPMT, TST, TMT1A GAA 4360/4885KMT2A 494/4885MAPT 1558/4885
US-20200071316-A1 ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE \"RIG-I\" PATHWAY AND METHODS OF USE THEREOF RARB, RARG, RARA GAA 1203/4885KMT2A 3906/4885MAPT 4826/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.