Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | METAP2 | P50579 | 7/20 | 0.43 |
| ▸ | METAP1 | P53582 | 6/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7712988 | 0.83 | SLC1A3 (0.51) | SMN1; SMN2MEN1KMT2ARAB9AMETAP2 | |
| SCHEMBL12557269 | 0.80 | RAB9A (0.45) | MEN1KMT2ARAB9ANPC1LMNA | |
| SCHEMBL1348207 | 0.80 | RAB9A (0.57) | SMN1; SMN2HPGDTSHRMEN1KMT2A | |
| SCHEMBL873555 | 0.80 | MTNR1A (0.48) | TSHRMETAP2METAP1ALDH1A1MAPT | |
| SCHEMBL3590919 | 0.79 | METAP2 (0.46) | TSHRMEN1KMT2AMETAP2METAP1 | |
| Propane SCHEMBL28029158 | 0.79 | RAB9A (0.55) | SMN1; SMN2HPGDTSHRRAB9ANPC1 | |
| Ethylamine SCHEMBL27536507 | 0.78 | MTNR1A (0.47) | HPGDRAB9ANPC1METAP2METAP1 | |
| Carbamic Acid SCHEMBL28253800 | 0.77 | RAB9A (0.54) | SMN1; SMN2HPGDTSHRRAB9ANPC1 | |
| SCHEMBL10728474 | 0.77 | METAP2 (0.45) | TSHRMEN1KMT2AMETAP2METAP1 | |
| SCHEMBL3646258 | 0.77 | MEN1 (0.52) | TSHRMEN1KMT2AMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261719-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | US | disclosed |
| EP-2193132-A2 | 3-SPIROPYRIMIDINETRIONE-QUINOLINE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | AstraZeneca AB (SE) | 2010-06-09 | — | — | EP | disclosed |
| WO-2009004382-A2 | 3-SPIROPYRIMIDINETRIONE-QUINOLINE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261719-A1 | CHEMICAL COMPOUNDS | NCOA3, NR4A3, NR0B2 | SMN1; SMN2 2367/4885HPGD 3393/4885TSHR 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.