Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.36 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.34 |
| ▸ | MGLL | Q99685 | 3/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30700757 | 0.83 | MGLL (0.38) | MGLL | |
| SCHEMBL30700419 | 0.83 | MGLL (0.38) | MGLL | |
| SCHEMBL30699974 | 0.82 | LIPE (0.42) | ABHD6MGLLPIK3CDPIK3R1 | |
| SCHEMBL30700376 | 0.81 | ABHD6 (0.39) | GPR119ABHD6LOXL2MGLLHCRTR1 | |
| SCHEMBL30700784 | 0.81 | GPR119 (0.37) | GPR119LOXL2HCRTR1HCRTR2 | |
| SCHEMBL30700334 | 0.81 | MGLL (0.36) | MGLLPIK3CDPIK3R1 | |
| SCHEMBL30700187 | 0.80 | MGLL (0.43) | MGLLPIK3CDPIK3R1 | |
| SCHEMBL25324569 | 0.80 | ABHD6 (0.37) | GPR119ABHD6LOXL2MGLLHCRTR1 | |
| SCHEMBL30553161 | 0.80 | ABHD6 (0.37) | GPR119ABHD6LOXL2MGLLHCRTR1 | |
| SCHEMBL30700429 | 0.79 | LIPE (0.35) | ABHD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |