Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | TEAD1 | P28347 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 9/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30699889 | 0.83 | FAAH (0.41) | P2RX7ENPP2 | |
| SCHEMBL30700088 | 0.82 | MGLL (0.41) | TEAD1 | |
| SCHEMBL30699918 | 0.82 | MGLL (0.41) | TEAD1 | |
| SCHEMBL30699915 | 0.81 | TEAD1 (0.41) | KCNH2TEAD1ENPP2 | |
| SCHEMBL30700502 | 0.79 | TEAD1 (0.39) | KCNH2TEAD1P2RX7 | |
| SCHEMBL30700033 | 0.79 | TACR1 (0.38) | EPHX2P2RX7ENPP2 | |
| SCHEMBL25323130 | 0.71 | PDE2A (0.37) | KCNH2TEAD1EPHX2P2RX7CHRNA7 | |
| SCHEMBL30700165 | 0.71 | MCHR1 (0.41) | KCNH2GPR119 | |
| SCHEMBL30699948 | 0.70 | MGLL (0.43) | TEAD1 | |
| SCHEMBL2930989 | 0.70 | TEAD1 (0.53) | TEAD1EPHX2P2RX7ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |