Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 6/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.37 |
| ▸ | ATXN2 | Q99700 | 6/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | F2R | P25116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30699918 | 0.87 | MGLL (0.41) | MCHR1F2R | |
| SCHEMBL30700088 | 0.87 | MGLL (0.41) | MCHR1F2R | |
| SCHEMBL30700502 | 0.80 | TEAD1 (0.39) | P2RX7MCHR1 | |
| SCHEMBL30700175 | 0.79 | KCNH2 (0.41) | P2RX7ENPP2EPHX2 | |
| SCHEMBL30699889 | 0.78 | FAAH (0.41) | P2RX7ENPP2 | |
| SCHEMBL30700699 | 0.77 | P2RX7 (0.38) | TACR1P2RX7ENPP2EPHX2ATXN2 | |
| SCHEMBL30699948 | 0.76 | MGLL (0.43) | MCHR1F2R | |
| SCHEMBL30699915 | 0.73 | TEAD1 (0.41) | ENPP2MCHR1F2R | |
| SCHEMBL30700165 | 0.72 | MCHR1 (0.41) | MCHR1 | |
| SCHEMBL25324356 | 0.72 | ENPP2 (0.42) | TACR1P2RX7ENPP2ATXN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |