Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 7/20 | 0.31 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30699966 | 0.85 | LOXL2 (0.33) | LOXL2GPR119 | |
| SCHEMBL30700784 | 0.84 | GPR119 (0.37) | MDM2LOXL2GPR119 | |
| SCHEMBL30700375 | 0.83 | LOXL2 (0.36) | MDM2LOXL2GPR119 | |
| SCHEMBL30700321 | 0.81 | MALT1 (0.36) | MALT1AXLTYRO3MERTKCYP2D6 | |
| SCHEMBL25326125 | 0.80 | MALT1 (0.38) | MALT1AXLTYRO3MERTKCYP2D6 | |
| SCHEMBL30553211 | 0.80 | MALT1 (0.38) | MALT1AXLTYRO3MERTKCYP2D6 | |
| SCHEMBL30700414 | 0.79 | ENPP2 (0.35) | — | |
| SCHEMBL30700261 | 0.79 | ENPP2 (0.35) | — | |
| SCHEMBL30700195 | 0.79 | ENPP2 (0.35) | — | |
| SCHEMBL30700117 | 0.75 | DPP4 (0.40) | MAP3K12CYP2D6DPP4HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |