Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 8/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30700018 | 0.95 | ENPP2 (0.39) | ENPP2CHRNA7PIK3CDPIK3R1JAK2 | |
| SCHEMBL30700127 | 0.88 | MGLL (0.42) | ENPP2CHRNA7PIK3CDPIK3R1JAK2 | |
| SCHEMBL30700110 | 0.86 | ENPP2 (0.39) | ENPP2CHRNA7PIK3CDPIK3R1JAK2 | |
| SCHEMBL30700145 | 0.82 | CHRNA7 (0.43) | CHRNA7SCN9A | |
| SCHEMBL30700475 | 0.81 | MGLL (0.38) | ENPP2CHRNA7PIK3CDPIK3R1JAK2 | |
| SCHEMBL30700282 | 0.80 | ENPP2 (0.38) | ENPP2PIK3CDPIK3R1JAK2JAK1 | |
| SCHEMBL30700368 | 0.77 | MGLL (0.40) | PIK3CDPIK3R1 | |
| SCHEMBL30700437 | 0.75 | MGLL (0.40) | PIK3CDPIK3R1JAK2JAK1PREP | |
| SCHEMBL30700053 | 0.71 | MGLL (0.40) | PIK3CD | |
| SCHEMBL30700845 | 0.71 | TRPC6 (0.39) | SCN9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |