Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29131022 | 0.84 | MAPT (0.38) | HSP90AA1MAPTHTTLMNAALDH1A1 | |
| SCHEMBL2084320 | 0.69 | — | — | |
| SCHEMBL11865950 | 0.68 | — | — | |
| SCHEMBL11916708 | 0.66 | — | — | |
| SCHEMBL2552339 | 0.65 | ALDH1A1 (0.46) | MAPTHTTLMNAALDH1A1 | |
| SCHEMBL20128357 | 0.65 | DAO (0.32) | — | |
| SCHEMBL15528571 | 0.64 | — | — | |
| SCHEMBL30979017 | 0.64 | MAPT (0.38) | HSP90AA1MAPTHTTLMNAALDH1A1 | |
| SCHEMBL27707617 | 0.62 | GPR84 (0.37) | HSP90AA1MAPTHTTALDH1A1 | |
| SCHEMBL14163807 | 0.61 | CA2 (0.34) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267713-A1 | 4,4-DISUBSTITUTED PIPERIDINES | HEROLD PETER | 2010-10-21 | — | — | US | disclosed |
| EP-2215088-A2 | 4,4-DISUBSTITUTED PIPERDINES AS RENIN INHIBITORS | Novartis AG (CH) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009056617-A2 | 4,4-DISUBSTITUTED PIPERDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267713-A1 | 4,4-DISUBSTITUTED PIPERIDINES | REN, AGTR2, AVPR2 | HSP90AA1 2025/4885MAPT 3847/4885HTT 3963/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.