Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 known ✓ | P30556 | 1/20 | 0.35 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MLNR | O43193 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL21905087 | 1.00 | KDM4E (0.39) | KDM4EALDH1A1BLMGAAHPGD | |
| Potassium SCHEMBL31514797 | 0.89 | MLNR (0.38) | KDM4EALDH1A1BLMMLNRNR1I2 | |
| SCHEMBL4292039 | 0.84 | FOLH1 (0.34) | KDM4EALDH1A1BLMMLNRNR1I2 | |
| SCHEMBL1368364 | 0.83 | KDM4E (0.53) | KDM4EALDH1A1BLMGAAHPGD | |
| SCHEMBL7751464 | 0.83 | LMNA (0.43) | KDM4EALDH1A1NR1I2MAPTTHRB | |
| SCHEMBL634844 | 0.82 | KDM4E (0.36) | KDM4EALDH1A1BLMGAAHPGD | |
| SCHEMBL25520341 | 0.82 | MLNR (0.39) | KDM4EALDH1A1BLMGAAHPGD | |
| SCHEMBL30519423 | 0.80 | BLM (0.53) | KDM4EALDH1A1BLMGAAHPGD | |
| SCHEMBL15240112 | 0.80 | BLM (0.53) | KDM4EALDH1A1BLMGAAHPGD | |
| SCHEMBL634270 | 0.80 | MAPT (0.42) | KDM4EALDH1A1BLMGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11866588-B2 | Polymerizable near-IR dyes | PROFUSA, INC. (US) | 2024-01-09 | — | — | US | disclosed |