Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9510197 | 0.91 | ALDH1A1 (0.40) | ALDH1A1TP53CYP3A4LMNAKMT2A | |
| SCHEMBL9515535 | 0.85 | ALDH1A1 (0.41) | ALDH1A1CYP3A4LMNAKMT2AMAPT | |
| SCHEMBL11531232 | 0.80 | LMNA (0.45) | ALDH1A1TP53LMNAKMT2AMAPT | |
| SCHEMBL20543639 | 0.80 | ALDH1A1 (0.39) | ALDH1A1CYP3A4LMNAKMT2AMAPT | |
| SCHEMBL27510653 | 0.76 | ALDH1A1 (0.51) | ALDH1A1TP53CYP3A4 | |
| SCHEMBL25075052 | 0.76 | ALDH1A1 (0.37) | ALDH1A1CYP3A4LMNAKMT2AMAPT | |
| SCHEMBL28049939 | 0.75 | CA2 (0.42) | ALDH1A1 | |
| SCHEMBL18095081 | 0.75 | SMN1; SMN2 (0.47) | ALDH1A1TP53CYP3A4LMNAKMT2A | |
| SCHEMBL24894079 | 0.75 | ALDH1A1 (0.30) | ALDH1A1LMNAKMT2AMAPTHPGD | |
| SCHEMBL9219750 | 0.75 | L3MBTL1 (0.41) | ALDH1A1LMNAKMT2AL3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4540255-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2025-04-23 | — | — | EP | disclosed |
| CN-119677749-A | Azaquinazoline pan KRAS inhibitors | 米拉蒂治疗股份有限公司 | 2025-03-21 | — | — | CN | disclosed |
| WO-2023244615-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-12-21 | — | — | WO | disclosed |