Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 20/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3056469 | 0.90 | CTSS (0.58) | CTSS | |
| SCHEMBL3080083 | 0.89 | CTSS (0.55) | CTSS | |
| SCHEMBL3060541 | 0.89 | CTSS (0.55) | CTSS | |
| SCHEMBL3068299 | 0.88 | CTSS (0.56) | CTSS | |
| SCHEMBL3056139 | 0.88 | CTSS (0.45) | CTSS | |
| SCHEMBL3070230 | 0.87 | CTSS (0.62) | CTSS | |
| SCHEMBL3066299 | 0.85 | CTSS (0.58) | CTSS | |
| SCHEMBL20584474 | 0.85 | CTSS (0.76) | CTSS | |
| SCHEMBL29417435 | 0.85 | CTSS (0.78) | CTSS | |
| SCHEMBL695184 | 0.85 | CTSS (0.78) | CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-B1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | HOFFMANN LA ROCHE (CH) | 2013-10-23 | — | — | EP | claimed |
| US-20100267722-A1 | NOVEL PROLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-21 | — | — | US | claimed |
| CN-108699044-B | Novel pyrrolidine derivatives | 豪夫迈·罗氏有限公司 | 2022-03-04 | — | — | CN | disclosed |
| US-10689339-B2 | Pyrrolidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2020-06-23 | — | — | US | disclosed |
| EP-3419970-A1 | NOVEL PYRROLIDINE DERIVATIVES | H. Hoffnabb-La Roche Ag (CH) | 2019-01-02 | — | — | EP | disclosed |
| US-20180362461-A1 | NOVEL PYRROLIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2018-12-20 | — | — | US | disclosed |
| WO-2017144483-A1 | NOVEL PYRROLIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2017-08-31 | — | — | WO | disclosed |
| EP-2421826-B1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | HOFFMANN LA ROCHE (CH) | 2013-10-23 | — | — | EP | disclosed |
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |
| US-20100267722-A1 | NOVEL PROLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180362461-A1 | NOVEL PYRROLIDINE DERIVATIVES | ARG2, PYCR1, ARG1 | CTSS 2797/4885 |
| US-10689339-B2 | Pyrrolidine derivatives | PYCR1, AVPR2, ARG2 | CTSS 2385/4885 |
| US-20100267722-A1 | NOVEL PROLINE DERIVATIVES | PRAP1, PRR12, SLC6A7 | CTSS 1542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.