SCHEMBL30737153

SCHEMBL30737153

COC(=O)c1ccc(Oc2cccc3c(C(=O)NCCCNC(=O)CCOCCOCCOCCOCCNc4ccc([N+](=O)[O-])cc4[N+](=O)[O-])cccc23)nc1

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HCAR3 P49019 1/20 0.38
MAPT P10636 8/20 0.38
ALDH1A1 P00352 5/20 0.38
PTGER4 P35408 1/20 0.38
RAB9A P51151 1/20 0.38
KMT2A Q03164 3/20 0.37
FOLH1 Q04609 4/20 0.36
PTGER3 P43115 1/20 0.36
KDM4E B2RXH2 2/20 0.36
MEN1 O00255 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
RGS12 O14924 1/20 0.35
LMNA P02545 1/20 0.35
HTT P42858 2/20 0.35
POLB P06746 1/20 0.35
THRB P10828 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30737232 0.94 HCAR3 (0.41) HCAR3MAPTALDH1A1KMT2AFOLH1
SCHEMBL30737421 0.90 FOLH1 (0.35) MAPTALDH1A1KMT2AFOLH1PTGER3
SCHEMBL30736995 0.87 SORT1 (0.45) HCAR3KMT2AFOLH1
SCHEMBL30737241 0.82 HDAC3 (0.37) MAPTALDH1A1KMT2AKDM4EMEN1
SCHEMBL30737086 0.80 PLK1 (0.38) KMT2APOLB
SCHEMBL31646647 0.79 HCAR3 (0.44) HCAR3MAPTALDH1A1PTGER4RAB9A
SCHEMBL30737162 0.73 F2 (0.41) KMT2AMEN1POLB
SCHEMBL31646191 0.72 HCAR3 (0.48) HCAR3MAPTALDH1A1PTGER4RAB9A
SCHEMBL30737309 0.71 GABRA5 (0.41) MAPTKDM4E
SCHEMBL30737273 0.67 PLK1 (0.47) KMT2AKDM4EMEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4543858-A1 BIFUNCTIONAL MOLECULES THAT SELECTIVELY INDUCE DEGRADATION OF EXTRACELLULAR TARGETS IN LYSOSOMES Draupnir Bio ApS (DK) 2025-04-30 EP disclosed
WO-2023247754-A1 BIFUNCTIONAL MOLECULES THAT SELECTIVELY INDUCE DEGRADATION OF EXTRACELLULAR TARGETS IN LYSOSOMES DRAUPNIR BIO APS (DK) 2023-12-28 WO disclosed