SCHEMBL30740908

SCHEMBL30740908

O=C(O)c1cc(OC(F)(F)F)c(O)c([N+](=O)[O-])c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TPMT P51580 1/20 0.48
TTR P02766 4/20 0.46
CASP6 P55212 1/20 0.45
AKR1C3 P42330 1/20 0.44
AKR1C2 P52895 1/20 0.44
LMNA P02545 1/20 0.42
TSHR P16473 1/20 0.42
ALDH1A1 P00352 1/20 0.41
GPR35 Q9HC97 1/20 0.41
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA3 P07451 1/20 0.40
PKM P14618 1/20 0.40
CA4 P22748 1/20 0.40
CA6 P23280 1/20 0.40
CA5A P35218 1/20 0.40
CA7 P43166 1/20 0.40
CA9 Q16790 1/20 0.40
CA14 Q9ULX7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2345173 0.81 CASP6 (0.58) TTRCASP6AKR1C3AKR1C2LMNA
SCHEMBL3903672 0.81 CASP6 (0.58) TTRCASP6AKR1C3AKR1C2LMNA
SCHEMBL31447584 0.80 CA12 (0.66) TPMTTTRCASP6TSHRALDH1A1
SCHEMBL3583434 0.80 CA12 (0.66) TPMTTTRCASP6TSHRALDH1A1
SCHEMBL30740978 0.79 CASP6 (0.49) TPMTTTRCASP6LMNATSHR
SCHEMBL503443 0.79 CASP6 (0.62) TPMTTTRCASP6LMNATSHR
Benzoic Acid SCHEMBL27864634 0.77 AKR1C3 (0.45) TPMTCASP6AKR1C3AKR1C2TSHR
SCHEMBL3647954 0.75 VCAM1 (0.47) ALDH1A1GPR35CA12CA1CA2
SCHEMBL3768831 0.74 TTR (0.55) TPMTTTRCASP6LMNATSHR
SCHEMBL644782 0.74 TTR (0.63) TPMTTTRCASP6LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260035341-A1 FTO INHIBITORS RPXDS CO LTD (CN) 2026-02-05 US disclosed
EP-4561975-A1 FTO INHIBITORS RPXDS Co., Ltd (CN) 2025-06-04 EP disclosed
CN-119546566-A FTO inhibitors 瑞璞鑫(苏州)生物科技有限公司 2025-02-28 CN disclosed
WO-2024022491-A1 FTO INHIBITORS RPXDS CO., LTD (CN) 2024-02-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035341-A1 FTO INHIBITORS FTO, LDLR, GPR119 TPMT 589/4885TTR 655/4885CASP6 1454/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.