Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBK | Q96KB5 | 5/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.39 |
| ▸ | PARP1 | P09874 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30751343 | 0.87 | ADORA1 (0.42) | PBKADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL30751437 | 0.79 | PARP1 (0.51) | PARP1 | |
| SCHEMBL6467180 | 0.77 | ADORA1 (0.44) | PBKADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL21174272 | 0.73 | NPC1 (0.44) | HPGDLMNACYP1A2CYP3A4SMN1; SMN2 | |
| SCHEMBL31456919 | 0.73 | LMNA (0.37) | ADORA3ADORA2AADORA1ADORA2BPARP1 | |
| SCHEMBL31456923 | 0.72 | ALDH1A1 (0.46) | ADORA2AADORA1ADORA2BHPGDLMNA | |
| SCHEMBL30751370 | 0.71 | CALCA (0.40) | PBKADORA2AADORA1ADORA2BMAPK1 | |
| SCHEMBL11480013 | 0.70 | PARP1 (0.39) | ADORA2AADORA2BPARP1HPGDSMN1; SMN2 | |
| SCHEMBL21174309 | 0.70 | PBK (0.38) | PBKADORA2AADORA1ADORA2B | |
| SCHEMBL30751428 | 0.69 | PBK (0.34) | PBKPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119654324-A | Novel compounds as hypoxia inducible factor 1 (HIF-1) inhibitors or Vascular Endothelial Growth Factor (VEGF) inhibitors and pharmaceutical compositions comprising the same | 株式会社次代生物科学 | 2025-03-18 | — | — | CN | claimed |
| CN-119654324-A | Novel compounds as hypoxia inducible factor 1 (HIF-1) inhibitors or Vascular Endothelial Growth Factor (VEGF) inhibitors and pharmaceutical compositions comprising the same | 株式会社次代生物科学 | 2025-03-18 | — | — | CN | disclosed |
| WO-2024030000-A1 | NOVEL COMPOUND AS HYPOXIA-INDUCIBLE FACTOR 1(HIF-1) INHIBITOR OR VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) INHIBITOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 넥스트젠바이오사이언스 | 2024-02-08 | — | — | WO | disclosed |