Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.33 |
| ▸ | MTOR | P42345 | 3/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30801838 | 0.87 | OTUD7B (0.35) | ROCK2ROCK1PRKCAFLT3GSK3B | |
| SCHEMBL30801809 | 0.87 | METAP2 (0.39) | ROCK2ROCK1FLT3METAP2PIK3CA | |
| SCHEMBL30801875 | 0.86 | TYRO3 (0.37) | ROCK2ALOX5APFEN1CYP2D6SLC6A2 | |
| SCHEMBL23574144 | 0.83 | USP30 (0.44) | ROCK2ROCK1PRKCAFLT3GSK3B | |
| SCHEMBL30986857 | 0.83 | USP30 (0.44) | ROCK2ROCK1PRKCAFLT3GSK3B | |
| SCHEMBL23574137 | 0.83 | USP30 (0.44) | ROCK2ROCK1PRKCAFLT3GSK3B | |
| SCHEMBL30801754 | 0.74 | CREBBP (0.35) | ROCK2METAP2CREBBP | |
| SCHEMBL30801871 | 0.72 | TYRO3 (0.34) | ROCK2CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL30801736 | 0.72 | USP30 (0.39) | ROCK2PRKCQMETAP2BRD4USP30 | |
| SCHEMBL23574073 | 0.70 | OTUD7B (0.44) | ROCK2ROCK1METAP2PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3793997-B1 | FUSED BICYCLIC COMPOUNDS USEFUL AS UBIQUITIN-SPECIFIC PEPTIDASE 30 INHIBITORS | FORMA THERAPEUTICS INC (US) | 2024-03-13 | — | — | EP | claimed |