Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 9/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 9/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 9/20 | 0.44 |
| ▸ | PDE2A | O00408 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 4/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCND2 | P30279 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.39 |
| ▸ | PDE6C | P51160 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1652844 | 0.80 | XDH (0.48) | PDE1APDE1BPDE1CPDE2APDE5A | |
| SCHEMBL2873217 | 0.79 | ALDH1A1 (0.45) | LMNAPKMTSHRMAPK1SMN1; SMN2 | |
| SCHEMBL2863823 | 0.69 | PKM (0.47) | LMNAPKMCYP1A2CYP3A4ADORA1 | |
| SCHEMBL2837094 | 0.69 | BRD4 (0.40) | LMNACYP1A2CYP3A4HTTGAA | |
| SCHEMBL9608334 | 0.68 | PDE1B (0.52) | PDE1APDE1BPDE1CPDE2ASMN1; SMN2 | |
| SCHEMBL194641 | 0.67 | PDE1B (0.73) | PDE1APDE1BPDE1CPDE2APDE5A | |
| SCHEMBL2454720 | 0.67 | PDE1B (0.50) | PDE1APDE1BPDE1CPDE2ALMNA | |
| SCHEMBL3666558 | 0.66 | PDE1B (0.72) | PDE1APDE1BPDE1CPDE2ALMNA | |
| SCHEMBL3081044 | 0.66 | PDE1B (0.57) | PDE1APDE1BPDE1CPDE2APDE5A | |
| SCHEMBL3091517 | 0.66 | PDE1B (0.72) | PDE1APDE1BPDE1CPDE2APDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240028-B1 | Pyrazolopyrimidine-4,6-dione derivatives and their use as pharmaceutical | INTRA CELLULAR THERAPIES INC (US) | 2016-07-20 | — | — | EP | disclosed |
| US-20150197524-A1 | ORGANIC COMPOUNDS | LI PENG (US) | 2015-07-16 | — | — | US | disclosed |
| US-8846693-B2 | Optionally substituted pyrazolo[3,4-d]pyrimidine-4,6-diones | INTRA-CELLULAR THERAPIES, INC. (US) | 2014-09-30 | — | — | US | disclosed |
| US-20100273753-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. | 2010-10-28 | — | — | US | disclosed |
| EP-2240028-A1 | ORGANIC COMPOUNDS | Intra-Cellular Therapies, Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009073210-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC (US) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273753-A1 | ORGANIC COMPOUNDS | OPRD1, PGR, HTR1D | PDE1A 102/4885PDE1B 147/4885PDE1C 234/4885 |
| US-20150197524-A1 | ORGANIC COMPOUNDS | OPRD1, HTR1D, DRD1 | PDE1A 77/4885PDE1B 115/4885PDE1C 182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.