Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.42 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.42 |
| ▸ | TYMP | P19971 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL431332 | 1.00 | HIF1A (0.46) | HIF1APOLBENPP1P2RY1TYMP | |
| SCHEMBL20129802 | 1.00 | HIF1A (0.46) | HIF1APOLBENPP1P2RY1TYMP | |
| SCHEMBL10022902 | 1.00 | HIF1A (0.46) | HIF1APOLBENPP1P2RY1TYMP | |
| SCHEMBL887467 | 1.00 | HIF1A (0.46) | HIF1APOLBENPP1P2RY1TYMP | |
| SCHEMBL25754040 | 0.88 | TYMP (0.43) | HIF1APOLBENPP1P2RY1TYMP | |
| SCHEMBL20095278 | 0.87 | HIF1A (0.48) | HIF1APOLBENPP1P2RY1TYMP | |
| SCHEMBL20016922 | 0.87 | HIF1A (0.50) | HIF1APOLBENPP1P2RY1TYMP | |
| SCHEMBL20129803 | 0.85 | HIF1A (0.63) | HIF1A | |
| SCHEMBL10022903 | 0.85 | HIF1A (0.63) | HIF1A | |
| SCHEMBL887520 | 0.85 | HIF1A (0.63) | HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12559797-B2 | Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2026-02-24 | — | — | US | disclosed |
| US-20240318245-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2024-09-26 | — | — | US | disclosed |
| US-11939631-B2 | Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2024-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12559797-B2 | Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators | POLN, DNMT3A, POLRMT | HIF1A 1114/4885POLB 5/4885ENPP1 1925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.