Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | PNP | P00491 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11688227 | 1.00 | HIF1A (0.63) | HIF1APNPLMNATP53HTT | |
| SCHEMBL29738724 | 1.00 | HIF1A (0.63) | HIF1APNPLMNATP53HTT | |
| SCHEMBL11688219 | 1.00 | HIF1A (0.63) | HIF1APNPLMNATP53HTT | |
| SCHEMBL10022903 | 1.00 | HIF1A (0.63) | HIF1APNPLMNATP53HTT | |
| SCHEMBL20129803 | 1.00 | HIF1A (0.63) | HIF1APNPLMNATP53HTT | |
| SCHEMBL17279176 | 0.88 | HIF1A (0.48) | HIF1A | |
| SCHEMBL17231789 | 0.88 | HIF1A (0.48) | HIF1A | |
| SCHEMBL20095278 | 0.88 | HIF1A (0.48) | HIF1A | |
| SCHEMBL3764696 | 0.87 | HIF1A (0.52) | HIF1APNPLMNATP53HTT | |
| SCHEMBL7661650 | 0.85 | HIF1A (0.52) | HIF1APNPLMNATP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10000801-B2 | Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-06-19 | — | — | US | disclosed |
| US-9932623-B2 | Nucleotide analogs | ABBOTT MOLECULAR INC. (US) | 2018-04-03 | — | — | US | disclosed |
| US-20170114403-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-04-27 | — | — | US | disclosed |
| US-9528151-B2 | Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-12-27 | — | — | US | disclosed |
| US-20150051113-A1 | NUCLEOTIDE ANALOGS | ABBOTT MOLECULAR INC. | 2015-02-19 | — | — | US | disclosed |
| US-20150051113-A1 | NUCLEOTIDE ANALOGS | ABBOTT MOLECULAR INC. | 2015-02-19 | — | — | US | disclosed |
| US-20150050697-A1 | NUCLEOTIDE ANALOGS | ABBOTT MOLECULAR INC. | 2015-02-19 | — | — | US | disclosed |
| US-20150050697-A1 | NUCLEOTIDE ANALOGS | ABBOTT MOLECULAR INC. | 2015-02-19 | — | — | US | disclosed |
| US-20140315191-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-10-23 | — | — | US | disclosed |
| US-20130280700-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2013-10-24 | — | — | US | disclosed |
| US-7883869-B2 | for sequencing single-stranded DNA by employing a nanopore and modified nucleotides | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2011-02-08 | — | — | US | disclosed |
| US-20100092952-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150050697-A1 | NUCLEOTIDE ANALOGS | NUDT1, NT5C3B, RNGTT | HIF1A 2005/4885PNP 10/4885LMNA 575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.