SCHEMBL30823802

SCHEMBL30823802

CSc1ccc([C@@H]2CNC(=O)[C@@H](c3ccc(F)cc3)C2)cc1

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MMP13 P45452 3/20 0.37
MMP1 P03956 2/20 0.37
ALDH1A1 P00352 1/20 0.37
MAPK1 P28482 1/20 0.37
MMP2 P08253 2/20 0.35
MMP3 P08254 1/20 0.35
MMP9 P14780 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
DDB1 Q16531 1/20 0.34
CRBN Q96SW2 1/20 0.34
TACR1 P25103 1/20 0.34
KCNH2 Q12809 1/20 0.34
MAP1LC3B Q9GZQ8 1/20 0.33
GAA P10253 1/20 0.33
TSHR P16473 1/20 0.33
ALPL P05186 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28653227 0.83 MMP13 (0.40) MMP13MMP1MMP2MMP3MMP9
SCHEMBL28653229 0.83 MMP13 (0.40) MMP13MMP1MMP2MMP3MMP9
SCHEMBL28648500 0.82 SLC6A3 (0.45) MMP13MMP1ALDH1A1MMP2MMP3
SCHEMBL28648497 0.82 SLC6A3 (0.45) MMP13MMP1ALDH1A1MMP2MMP3
SCHEMBL28645234 0.81 FPR1 (0.48) MMP13MMP1ALDH1A1MMP2MMP3
SCHEMBL28661891 0.81 ADRB2 (0.41) MMP13MMP1ALDH1A1MMP2MMP3
SCHEMBL28658169 0.81 NAAA (0.40) MMP13MMP1MAPK1MMP2MMP3
SCHEMBL28658170 0.81 NAAA (0.40) MMP13MMP1MAPK1MMP2MMP3
SCHEMBL28661893 0.81 ADRB2 (0.41) MMP13MMP1ALDH1A1MMP2MMP3
SCHEMBL28645237 0.81 FPR1 (0.48) MMP13MMP1ALDH1A1MMP2MMP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113461599-B Process for preparing piperidone compounds 南方科技大学 2024-02-09 CN disclosed