Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Isopropamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 7/20 | 0.97 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.94 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.94 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isopropamide SCHEMBL100256 | 0.98 | CHRM3 (1.00) | CHRM3CHRM2KCNH2CYP2D6LMNA | |
| Isopropamide SCHEMBL100255 | 0.97 | KDM4E (1.00) | CHRM3CHRM2KCNH2CYP2D6LMNA | |
| Isopropamide SCHEMBL14672609 | 0.96 | CHRM3 (0.94) | CHRM3CHRM2KCNH2CYP2D6LMNA | |
| Isopropamide SCHEMBL7796559 | 0.91 | CHRM3 (0.85) | CHRM3CHRM2KCNH2CYP2D6LMNA | |
| SCHEMBL4538265 | 0.88 | CHRM3 (0.80) | CHRM3CHRM2KCNH2CYP2D6LMNA | |
| Isopropamide SCHEMBL17923572 | 0.86 | KDM4E (0.79) | CHRM3CHRM2KCNH2CYP2D6LMNA | |
| Ambutonium SCHEMBL11946672 | 0.79 | CHRM3 (0.67) | CHRM3CHRM2KCNH2CYP2D6LMNA | |
| Ambutonium SCHEMBL249674 | 0.78 | CHRM3 (0.65) | CHRM3CHRM2KCNH2CYP2D6LMNA | |
| SCHEMBL25341236 | 0.76 | CHRM3 (0.63) | CHRM3CHRM2KCNH2CYP2D6LMNA | |
| Hydrochloric Acid SCHEMBL30307081 | 0.75 | CHRM3 (0.61) | CHRM3CHRM2KCNH2CYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210163409-A1 | ALTERNATE PROCESSES FOR THE PREPARATION OF PYRROLIDINE DERIVATIVES | Dr Reddys Laboratories Ltd (IN) | 2021-06-03 | — | — | US | disclosed |
| WO-2019016745-A1 | ALTERNATE PROCESSES FOR THE PREPARATION OF PYRROLIDINE DERIVATIVES | DR. REDDY'S LABORATORIES LIMITED (IN) | 2019-01-24 | — | — | WO | disclosed |
| EP-1732895-B1 | INSECTICIDAL N-SUBSTITUTED SULFOXIMINES | DOW AGROSCIENCES LLC (US) | 2016-11-16 | — | — | EP | disclosed |
| CN-1942442-B | Insecticidal N-substituted sulfenimides | DOW AGROSCIENCES LLC | 2012-10-31 | — | — | CN | disclosed |
| CN-101648906-B | Insecticidal N-substituted sulfoximines | DOW AGROSCIENCES LLC | 2012-07-11 | — | — | CN | disclosed |
| US-7897782-B2 | [3-(6-Chloropyridin-3-yl)-2-methylpropyl](methyl)oxido- lambda 4-sulfanylidenecyanamide; aphidicides | DOW AGROSCIENCES LLC (US) | 2011-03-01 | — | — | US | disclosed |
| US-7834188-B2 | Insecticidal N-substituted sulfoximines | DOW AGROSCIENCES LLC (US) | 2010-11-16 | — | — | US | disclosed |
| US-7829719-B2 | Insecticidal N-substituted sulfoximines | DOW AGROSCIENCES LLC (US) | 2010-11-09 | — | — | US | disclosed |
| US-7795456-B2 | Insecticidal N-substituted sulfoximines | DOW AGROSCIENCES LLC (US) | 2010-09-14 | — | — | US | disclosed |
| US-20100076032-A1 | INSECTICIDAL N-SUBSTITUTED SULFOXIMINES | DOW AGROSCIENCES LLC (US) | 2010-03-25 | — | — | US | disclosed |
| WO-2006060029-A2 | INSECTICIDAL N-SUBSTITUTED SULFOXIMINES | DOW AGROSCIENCES LLC (US) | 2006-06-08 | — | — | WO | disclosed |
| US-20050228027-A1 | Insecticidal N-substituted sulfoximines | CORTEVA AGRISCIENCE LLC | 2005-10-13 | — | — | US | disclosed |
| US-4479003-A | Heterocyclic-hydroxy-substituted carboxylate esters | PHILIP MORRIS, INCORPORATED (US) | 1984-10-23 | — | — | US | disclosed |
| US-4474819-A | Flavored foodstuffs | PHILIP MORRIS, INCORPORATED (US) | 1984-10-02 | — | — | US | disclosed |
| EP-0015073-B1 | SMOKING, FLAVORED AND FOODSTUFF COMPOSITIONS | PHILIP MORRIS INCORPORATED (US) | 1983-05-18 | — | — | EP | disclosed |
| EP-0037163-A2 | Flavouring agents, smoking compositions, combustible articles and foodstuffs containing such agents, and a method of producing the same | PHILIP MORRIS INCORPORATED (US) | 1981-10-07 | — | — | EP | disclosed |
| US-4259969-A | HYDROXYALKYLPYRAZINES AND -PYRIDINES | PHILIP MORRIS INCORPORATED (US) | 1981-04-07 | — | — | US | disclosed |
| EP-0015073-A1 | Smoking, flavored and foodstuff compositions | PHILIP MORRIS INCORPORATED (US) | 1980-09-03 | — | — | EP | disclosed |
| US-4112236-A | Interphenylene 8-aza-9-dioxothia-11,12-secoprostaglandins | MERCK & CO., INC. (US) | 1978-09-05 | — | — | US | disclosed |
| US-4046760-A | Process for preparing 1-α-hydroxy cholesterol derivatives | MERCK & CO., INC. (US) | 1977-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210163409-A1 | ALTERNATE PROCESSES FOR THE PREPARATION OF PYRROLIDINE DERIVATIVES | PRKD1, JAK1, JAK3 | CHRM3 4816/4885CHRM1 4720/4885CHRM2 4786/4885 |
| US-20100076032-A1 | INSECTICIDAL N-SUBSTITUTED SULFOXIMINES | GSS, STS, SMS | CHRM3 1386/4885CHRM1 2488/4885CHRM2 2170/4885 |
| US-20050228027-A1 | Insecticidal N-substituted sulfoximines | GSS, STS, SMS | CHRM3 1386/4885CHRM1 2488/4885CHRM2 2170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.