Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Ambutonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 11/20 | 0.65 |
| ▸ | CHRM2 known ✓ | P08172 | 8/20 | 0.65 |
| ▸ | CHRM1 known ✓ | P11229 | 4/20 | 0.65 |
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.48 |
| ▸ | CHRM4 known ✓ | P08173 | 3/20 | 0.42 |
| ▸ | CHRM5 known ✓ | P08912 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.63 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | SCN1A | P35498 | 2/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ambutonium SCHEMBL11946672 | 0.98 | CHRM3 (0.67) | CHRM3CHRM2CHRM1KCNH2LMNA | |
| Isopropamide SCHEMBL100256 | 0.79 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2LMNA | |
| SCHEMBL9295790 | 0.79 | CHRM3 (0.59) | CHRM3CHRM2CHRM1KCNH2LMNA | |
| Isopropamide SCHEMBL3082703 | 0.78 | CHRM3 (0.97) | CHRM3CHRM2CHRM1KCNH2LMNA | |
| Isopropamide SCHEMBL100255 | 0.78 | KDM4E (1.00) | CHRM3CHRM2CHRM1KCNH2LMNA | |
| Isopropamide SCHEMBL14672609 | 0.77 | CHRM3 (0.94) | CHRM3CHRM2CHRM1KCNH2LMNA | |
| SCHEMBL2984162 | 0.76 | CHRM3 (0.56) | CHRM3CHRM2CHRM1KCNH2LMNA | |
| Isopropamide SCHEMBL7796559 | 0.75 | CHRM3 (0.85) | CHRM3CHRM2CHRM1KCNH2LMNA | |
| SCHEMBL4030430 | 0.75 | MAPT (0.55) | CHRM3CHRM2CHRM1KCNH2LMNA | |
| Hydrochloric Acid SCHEMBL30448099 | 0.74 | CHRM3 (0.55) | CHRM3CHRM2CHRM1KCNH2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 152 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101326275-A | Multifunctional ionic liquid composition | UNIV ALABAMA (US) | 2008-12-17 | — | — | CN | claimed |
| CN-1294519-A | Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient | INPHARMA SA (CH) | 2001-05-09 | — | — | CN | claimed |
| US-5008111-A | Pretreating skin with anticholinergic quaternary ammonium salt to suppress perspiration | SCHERING CORPORATION (US) | 1991-04-16 | — | — | US | claimed |
| US-4824676-A | ANTICHOLINERGIC AGENT TO SUPPRESS PERSPIRATION | SCHERING CORPORATION (US) | 1989-04-25 | — | — | US | claimed |
| US-20260133211-A1 | REAGENT FOR MEASURING ACTIVATED PARTIAL THROMBOPLASTIN TIME, AND BLOOD COAGULATION TIME REGULATOR FOR LUPUS ANTICOAGULANT-POSITIVE BLOOD SPECIMEN OR HEPARIN-CONTAINING BLOOD SPECIMEN | SEKISUI MEDICAL CO., LTD. (JP) | 2026-05-14 | — | — | US | disclosed |
| US-12571021-B2 | Methods for quantifying starch and cellulose in corn samples | EDENIQ, INC. (US) | 2026-03-10 | — | — | US | disclosed |
| EP-4603841-A1 | REAGENT FOR MEASURING ACTIVATED PARTIAL THROMBOPLASTIN TIME, AND BLOOD COAGULATION TIME REGULATOR FOR LUPUS ANTICOAGULANT-POSITIVE BLOOD SPECIMEN OR HEPARIN-CONTAINING BLOOD SPECIMEN | Sekisui Medical Co., Ltd. (JP) | 2025-08-20 | — | — | EP | disclosed |
| WO-2025135129-A1 | AGENT FOR IMPROVING AGGLUTINATION REACTION, METHOD FOR IMPROVING TARGET ANTIGEN MEASUREMENT METHOD, AND REAGENT FOR MEASURING HUMAN BRAIN NATRIURETIC PEPTIDE | デンカ株式会社 | 2025-06-26 | — | — | WO | disclosed |
| CN-120019282-A | Reagent for measuring activated partial thromboplastin time and clotting time regulator for lupus anticoagulant positive blood sample or heparin-containing blood sample | 积水医疗株式会社 | 2025-05-16 | — | — | CN | disclosed |
| US-20240360491-A1 | METHODS FOR QUANTIFYING STARCH AND CELLULOSE IN CORN SAMPLES | EDENIQ, INC. (US) | 2024-10-31 | — | — | US | disclosed |
| US-12054767-B2 | Methods for quantifying starch cellulose in corn samples | EDENIQ, INC. (US) | 2024-08-06 | — | — | US | disclosed |
| US-20240074995-A1 | METHODS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH AN ABNORMAL INFLAMMATORY RESPONSES | FIRST WAVE BIO, INC. | 2024-03-07 | — | — | US | disclosed |
| US-20020102217-A1 | Diagnostic/therapeutic agents | NYCOMED IMAGING AS | 2002-08-01 | — | — | US | disclosed |
| US-6331289-B1 | ULTRASOUND CONTRAST AGENTS, SUSPENSION IN AQUEOUS CARRIER LIQUID OF A REPORTER COMPRISING GAS-CONTAINING OR GAS-GENERATING MATERIAL, AGENT CAPABLE OF FORMING AT LEAST TWO TYPES OF BINDING PAIRS WITH TARGET; REPORTER BEING CONJUGATED | NYCOMED IMAGING AS (NO) | 2001-12-18 | — | — | US | disclosed |
| US-6264917-B1 | MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT | NYCOMED IMAGING AS (NO) | 2001-07-24 | — | — | US | disclosed |
| US-6261537-B1 | TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES | NYCOMED IMAGING AS (NO) | 2001-07-17 | — | — | US | disclosed |
| CN-1294519-A | Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient | INPHARMA SA (CH) | 2001-05-09 | — | — | CN | disclosed |
| CN-1218692-A | Novel Anti-spasmodic composition and process for manufacture thereof | PANACEA BIOTEC LTD (IN) | 1999-06-09 | — | — | CN | disclosed |
| EP-0198034-A1 | PHYSIOLOGICAL MEANS OF ENHANCING TRANSDERMAL DELIVERY OF DRUGS. | KEY PHARMA (US) | 1986-10-22 | — | — | EP | disclosed |
| WO-1986002272-A1 | PHYSIOLOGICAL MEANS OF ENHANCING TRANSDERMAL DELIVERY OF DRUGS | KEY PHARMACEUTICALS, INC. (US) | 1986-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240074995-A1 | METHODS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH AN ABNORMAL INFLAMMATORY RESPONSES | FH, CS, ECHS1 | CHRM3 2637/4885CHRM2 2534/4885CHRM1 4149/4885 |
| US-12571021-B2 | Methods for quantifying starch and cellulose in corn samples | TREH, TALDO1, CEL | CHRM3 3813/4885CHRM2 2704/4885CHRM1 2157/4885 |
| US-20260133211-A1 | REAGENT FOR MEASURING ACTIVATED PARTIAL THROMBOPLASTIN TIME, AND BLOOD COAGULATION TIME REGULATOR FOR LUPUS ANTICOAGULANT-POSITIVE BLOOD SPECIMEN OR HEPARIN-CONTAINING BLOOD SPECIMEN | TFPI, SSB, F2 | CHRM3 4331/4885CHRM2 4150/4885CHRM1 4185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.