Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | CCNK | O75909 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CCND3 | P30281 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.49 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | INSR | P06213 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.48 |
| ▸ | ULK1 | O75385 | 1/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30833672 | 0.87 | ALK (0.51) | EGFRCCNKCCNA2CDK2CCND3 | |
| SCHEMBL30833785 | 0.85 | ALK (0.51) | EGFRALKIGF1RMAPK9MAPK10 | |
| SCHEMBL29190631 | 0.85 | IGF1R (0.44) | EGFRALKIGF1RPTK2 | |
| SCHEMBL30833687 | 0.84 | ALK (0.50) | EGFRALKMAPK9MAPK10ULK1 | |
| SCHEMBL29190617 | 0.84 | ALK (0.68) | EGFRCCNKCCNA2CDK2CCND3 | |
| SCHEMBL29190716 | 0.83 | FGFR1 (0.44) | EGFRCDK2ALKIGF1RPTK2 | |
| SCHEMBL30833656 | 0.83 | ALK (0.48) | ALKAXLIGF1R | |
| SCHEMBL30833633 | 0.81 | EGFR (0.47) | EGFRCDK2ALKPTK2PTK2B | |
| SCHEMBL30833661 | 0.79 | ALK (0.46) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL30833669 | 0.77 | ALK (0.46) | CCNKCCNA2CDK2CCND3CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113896744-B | Selective EGFR inhibitor | 成都先导药物开发股份有限公司 | 2024-04-16 | — | — | CN | disclosed |