Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.52 |
| ▸ | FLT3 | P36888 | 4/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.52 |
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.52 |
| ▸ | PAK4 | O96013 | 3/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.52 |
| ▸ | LCK | P06239 | 3/20 | 0.52 |
| ▸ | CSF1R | P07333 | 3/20 | 0.52 |
| ▸ | RET | P07949 | 3/20 | 0.52 |
| ▸ | IGF1R | P08069 | 3/20 | 0.52 |
| ▸ | MET | P08581 | 3/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.52 |
| ▸ | PRKACA | P17612 | 3/20 | 0.52 |
| ▸ | FLT1 | P17948 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30833661 | 0.84 | ALK (0.46) | FLT3ALKIGF1RCDK9ULK1 | |
| SCHEMBL30833785 | 0.84 | ALK (0.51) | MAPK9FLT3ALKIGF1RAURKA | |
| SCHEMBL30833724 | 0.84 | ALK (0.52) | KDRMAPK9ROCK1FLT3ALK | |
| SCHEMBL30833687 | 0.83 | ALK (0.50) | MAPK9FLT3ALKMETULK1 | |
| SCHEMBL30833783 | 0.81 | SYK (0.47) | FLT3ALKDAPK3JAK2PRKD3 | |
| SCHEMBL30833669 | 0.81 | ALK (0.46) | FLT3ALKMETCDK9ULK1 | |
| SCHEMBL30833656 | 0.81 | ALK (0.48) | FLT3ALKIGF1R | |
| SCHEMBL29190607 | 0.80 | ALK (0.63) | KDRMAPK9ROCK1FLT3ALK | |
| SCHEMBL30833641 | 0.80 | SYK (0.47) | KDRMAPK9ROCK1FLT3ALK | |
| SCHEMBL16966149 | 0.80 | PTK2 (0.45) | FLT3ALKPTK2METINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113896744-B | Selective EGFR inhibitor | 成都先导药物开发股份有限公司 | 2024-04-16 | — | — | CN | disclosed |