Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 6/20 | 0.47 |
| ▸ | JAK1 | P23458 | 6/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.46 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30833696 | 0.91 | ALK (0.52) | ALKPTK2METFLT3MAPK9 | |
| SCHEMBL30833797 | 0.85 | ALK (0.44) | JAK3JAK1ALKPKMYT1IGF1R | |
| SCHEMBL29190642 | 0.84 | ALK (0.59) | JAK3JAK1ALKPKMYT1EGFR | |
| SCHEMBL30833757 | 0.81 | ALK (0.47) | ALKPTK2METCDK2FLT3 | |
| SCHEMBL30833666 | 0.81 | ALK (0.49) | ALKIGF1REGFRMETFLT3 | |
| SCHEMBL30833776 | 0.80 | ALK (0.48) | ALKSYKPTK2METFLT3 | |
| SCHEMBL30833764 | 0.78 | IGF1R (0.45) | JAK3JAK1ALKSYKIGF1R | |
| SCHEMBL30833774 | 0.76 | IGF1R (0.43) | JAK3ALKSYKIGF1RAURKA | |
| SCHEMBL29190551 | 0.76 | ALK (0.67) | ALKPTK2EGFRMETFLT3 | |
| SCHEMBL30833765 | 0.75 | PKMYT1 (0.38) | ALKPKMYT1IGF1RAURKAINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113896744-B | Selective EGFR inhibitor | 成都先导药物开发股份有限公司 | 2024-04-16 | — | — | CN | disclosed |