Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 12/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | BCL6 | P41182 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30833627 | 0.88 | BCL6 (0.39) | AURKAMAPK8ALKBCL6IGF1R | |
| SCHEMBL30833628 | 0.85 | IGF1R (0.46) | MAPK8ALKIGF1RKMT2ANTRK1 | |
| SCHEMBL30833663 | 0.85 | PIN1 (0.36) | IGF1RKMT2ACDK1PTK2 | |
| SCHEMBL30833645 | 0.85 | PIN1 (0.36) | IGF1RKMT2ACDK1PTK2 | |
| SCHEMBL30833754 | 0.85 | MAPT (0.36) | AURKAIGF1RKMT2ACDK1CDK2 | |
| SCHEMBL30833638 | 0.85 | PTK2 (0.45) | JAK2CDC7IGF1RMAP4K4NTRK1 | |
| SCHEMBL30833793 | 0.81 | MAPT (0.34) | KMT2A | |
| SCHEMBL30833659 | 0.78 | AURKA (0.48) | AURKAGLO1AURKBJAK2ALDH1A1 | |
| SCHEMBL15492039 | 0.76 | AURKA (0.68) | AURKAGLO1AURKBJAK2ALDH1A1 | |
| SCHEMBL30833726 | 0.74 | IGF1R (0.40) | AURKAGLO1AURKBALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113896744-B | Selective EGFR inhibitor | 成都先导药物开发股份有限公司 | 2024-04-16 | — | — | CN | disclosed |