Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.46 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.46 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30885710 | 0.93 | CYP3A4 (0.46) | CYP3A4TSHRALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL30885702 | 0.93 | CYP3A4 (0.46) | CYP3A4TSHRALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL30885709 | 0.90 | ALDH1A1 (0.49) | CYP3A4TSHRALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL31734749 | 0.78 | ABCC8 (0.51) | CYP3A4TSHRALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL7950622 | 0.77 | ABCC8 (0.73) | CYP3A4TSHRALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL7950905 | 0.75 | ABCC8 (0.56) | CYP3A4TSHRALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL5620778 | 0.72 | ALDH1A1 (0.49) | CYP3A4TSHRALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL7956978 | 0.71 | ALDH1A1 (0.51) | CYP3A4TSHRALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL30885705 | 0.71 | ALDH1A1 (0.44) | CYP3A4TSHRALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL4258379 | 0.71 | THRB (0.39) | CYP3A4TSHRALDH1A1CYP2D6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250360142-A1 | NOVEL ATP-SENSITIVE POTASSIUM CHANNEL POTENTIATORS, THEIR PREPARATION AND USE | RHYTHM PHARMACEUTICALS INC (US) | 2025-11-27 | — | — | US | disclosed |
| EP-4605383-A1 | NOVEL ATP-SENSITIVE POTASSIUM CHANNEL POTENTIATORS, THEIR PREPARATION AND USE | Rhythm Pharmaceuticals, Inc. (US) | 2025-08-27 | — | — | EP | disclosed |
| WO-2024086252-A1 | NOVEL ATP-SENSITIVE POTASSIUM CHANNEL POTENTIATORS, THEIR PREPARATION AND USE | RHYTHM PHARMACEUTICALS, INC. (US) | 2024-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250360142-A1 | NOVEL ATP-SENSITIVE POTASSIUM CHANNEL POTENTIATORS, THEIR PREPARATION AND USE | KCNJ11, ATP1A2, ATP1A3 | CYP3A4 1529/4885TSHR 2180/4885ALDH1A1 2043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.