Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 5/20 | 0.76 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | IKBKB | O14920 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.47 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7639339 | 0.84 | CHEK2 (0.57) | CHEK2CHEK1CYP2E1CYP2A6CYP2B6 | |
| SCHEMBL27623966 | 0.83 | CHEK2 (0.56) | CHEK2CHEK1CYP2E1CYP2A6CYP2B6 | |
| SCHEMBL203627 | 0.82 | LCK (0.59) | CHEK2CA12CA1CA2CA9 | |
| SCHEMBL6516791 | 0.80 | HSD17B1 (0.55) | CHEK2CHEK1CYP2E1CYP2A6CYP2B6 | |
| SCHEMBL7334475 | 0.80 | CHEK2 (0.53) | CHEK2CHEK1CYP2E1CYP2A6CYP2B6 | |
| SCHEMBL1002578 | 0.80 | CA2 (0.67) | CA12CA1CA2CA9CA14 | |
| SCHEMBL6664611 | 0.78 | CHEK2 (0.55) | CHEK2CHEK1CYP2E1CYP2A6CYP2B6 | |
| SCHEMBL27989815 | 0.78 | CYP2A6 (0.74) | CHEK2CYP2E1CYP2A6CYP2B6ACMSD | |
| SCHEMBL5944164 | 0.77 | HDAC1 (0.63) | CHEK2CA12CA1CA9MMP2 | |
| SCHEMBL826805 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240075025-A1 | Therapy for Mitochondrial Fatty Acid Beta-Oxidation and Transport Disorders | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2024-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240075025-A1 | Therapy for Mitochondrial Fatty Acid Beta-Oxidation and Transport Disorders | HADHB, HADHA, NDUFAB1 | CHEK2 4804/4885CHEK1 4733/4885CA12 4873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.