Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35211500 | 0.75 | METAP2 (0.39) | TRPA1RXRARXRBRXRGMETAP2 | |
| SCHEMBL35211775 | 0.75 | METAP2 (0.39) | TRPA1RXRARXRBRXRGMETAP2 | |
| SCHEMBL35211473 | 0.71 | MAPK1 (0.39) | TRPA1RXRARXRBRXRGMETAP2 | |
| SCHEMBL2426106 | 0.71 | METAP2 (0.42) | TRPA1RXRARXRBRXRGMETAP2 | |
| SCHEMBL30911391 | 0.71 | NT5E (0.34) | ALDH1A1 | |
| SCHEMBL35211499 | 0.69 | TRPA1 (0.37) | TRPA1RXRARXRBRXRGMETAP2 | |
| SCHEMBL35210889 | 0.67 | RXRA (0.36) | TRPA1RXRARXRBRXRGMETAP2 | |
| SCHEMBL35211095 | 0.66 | TRPA1 (0.35) | TRPA1RXRARXRBRXRGMETAP2 | |
| SCHEMBL2427659 | 0.66 | ERN1 (0.40) | TRPA1RXRARXRBRXRGMETAP2 | |
| SCHEMBL29935824 | 0.66 | NOS1 (0.39) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024074977-A1 | SUBSTITUTED 1 H-PYRAZOLO-PYRIDINE AND-PYRIMIDINE COMPOUNDS | PFIZER INC. (US) | 2024-04-11 | — | — | WO | disclosed |