Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 6/20 | 0.38 |
| ▸ | NOS1 | P29475 | 4/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NT5E | P21589 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35211775 | 0.79 | METAP2 (0.39) | METAP2TRPA1NOS1TRPM8TRPV1 | |
| SCHEMBL10850431 | 0.75 | NT5E (0.42) | METAP2TRPA1NOS1TRPM8TRPV1 | |
| SCHEMBL22291031 | 0.75 | NOS1 (0.44) | METAP2TRPA1NOS1DYRK1AHTT | |
| SCHEMBL30966926 | 0.75 | NOS1 (0.44) | METAP2TRPA1NOS1DYRK1AHTT | |
| SCHEMBL35211473 | 0.75 | MAPK1 (0.39) | METAP2TRPA1TRPM8RXRARXRB | |
| SCHEMBL30911436 | 0.75 | TRPA1 (0.36) | METAP2TRPA1TRPM8RXRARXRB | |
| SCHEMBL2630725 | 0.74 | METAP2 (0.41) | METAP2TRPA1NOS1TRPM8TRPV1 | |
| SCHEMBL35211499 | 0.72 | TRPA1 (0.37) | METAP2TRPA1TRPM8TRPV1RXRA | |
| SCHEMBL27309205 | 0.72 | NOS1 (0.41) | METAP2TRPA1NOS1DYRK1A | |
| SCHEMBL31206793 | 0.72 | NOS1 (0.41) | METAP2TRPA1NOS1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260125375-A1 | SUBSTITUTED 1H-PYRAZOLO-PYRIDINE AND -PYRIMIDINE COMPOUNDS | PFIZER INC. (US) | 2026-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260125375-A1 | SUBSTITUTED 1H-PYRAZOLO-PYRIDINE AND -PYRIMIDINE COMPOUNDS | CCR1, CCR6, CCRL2 | METAP2 3861/4885TRPA1 3698/4885NOS1 3221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.