Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 3/20 | 0.33 |
| ▸ | CD38 | P28907 | 8/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35211473 | 0.76 | MAPK1 (0.39) | RXRARXRBRXRGTRPA1METAP2 | |
| SCHEMBL35211095 | 0.70 | TRPA1 (0.35) | RXRARXRBRXRGTRPA1METAP2 | |
| SCHEMBL35211775 | 0.70 | METAP2 (0.39) | RXRARXRBRXRGTRPA1METAP2 | |
| SCHEMBL35211500 | 0.70 | METAP2 (0.39) | RXRARXRBRXRGTRPA1METAP2 | |
| SCHEMBL35211499 | 0.68 | TRPA1 (0.37) | RXRARXRBRXRGTRPA1METAP2 | |
| SCHEMBL30911436 | 0.67 | TRPA1 (0.36) | RXRARXRBRXRGTRPA1METAP2 | |
| SCHEMBL10850431 | 0.61 | NT5E (0.42) | TRPA1METAP2 | |
| SCHEMBL20106902 | 0.61 | RXRA (0.47) | RXRARXRBRXRGTRPA1METAP2 | |
| SCHEMBL12479638 | 0.60 | METAP2 (0.49) | TRPA1METAP2 | |
| SCHEMBL13961150 | 0.59 | METAP2 (0.47) | RXRARXRBRXRGTRPA1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260125375-A1 | SUBSTITUTED 1H-PYRAZOLO-PYRIDINE AND -PYRIMIDINE COMPOUNDS | PFIZER INC. (US) | 2026-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260125375-A1 | SUBSTITUTED 1H-PYRAZOLO-PYRIDINE AND -PYRIMIDINE COMPOUNDS | CCR1, CCR6, CCRL2 | RXRA 324/4885RXRB 398/4885RXRG 452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.