Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.40 |
| ▸ | DRD3 | P35462 | 5/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10354317 | 0.80 | DRD2 (0.49) | DRD4LMNAPOLBDRD2DRD3 | |
| SCHEMBL3097820 | 0.77 | ALDH1A1 (0.45) | DRD4ALDH1A1LMNAPOLBDRD2 | |
| SCHEMBL3097419 | 0.76 | SIGMAR1 (0.44) | DRD4ALDH1A1TSHRALOX15TDP1 | |
| SCHEMBL10827328 | 0.75 | DRD4 (0.49) | DRD4DRD2DRD3HTR1ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL11020008 | 0.74 | DRD4 (0.48) | DRD4DRD2DRD3HTR1ASIGMAR1 | |
| SCHEMBL1822876 | 0.74 | HTR1A (0.46) | DRD4TDP1LMNAPOLBDRD2 | |
| SCHEMBL6621542 | 0.73 | SIGMAR1 (0.52) | DRD4ALDH1A1TDP1LMNAPOLB | |
| SCHEMBL10827696 | 0.71 | DRD2 (0.49) | ALDH1A1ALOX15DRD2DRD3SIGMAR1 | |
| SCHEMBL1824893 | 0.71 | SIGMAR1 (0.40) | DRD4ALDH1A1POLBDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL11019494 | 0.70 | DRD2 (0.48) | ALDH1A1ALOX15DRD2DRD3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919908-B1 | TRIAZOLE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LTD (GB) | 2010-11-10 | — | — | EP | disclosed |
| EP-1919908-B1 | TRIAZOLE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LTD (GB) | 2010-11-10 | — | — | EP | disclosed |
| US-7799815-B2 | Triazole derivatives as modulators of dopamine D3 receptors | GLAXO GROUP LIMITED (GB) | 2010-09-21 | — | — | US | disclosed |
| US-7799815-B2 | Triazole derivatives as modulators of dopamine D3 receptors | GLAXO GROUP LIMITED (GB) | 2010-09-21 | — | — | US | disclosed |
| US-7799815-B2 | Triazole derivatives as modulators of dopamine D3 receptors | GLAXO GROUP LIMITED (GB) | 2010-09-21 | — | — | US | disclosed |
| US-20090221593-A1 | TRIAZOLE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-09-03 | — | — | US | disclosed |
| US-20090221593-A1 | TRIAZOLE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-09-03 | — | — | US | disclosed |
| US-20090221593-A1 | TRIAZOLE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-09-03 | — | — | US | disclosed |
| WO-2007022933-A1 | TRIAZOLE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2007-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221593-A1 | TRIAZOLE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | DRD3, HTR5A, HTR3C | DRD4 14/4885ALDH1A1 2304/4885TSHR 181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.