Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28688493 | 0.81 | TSHR (0.51) | TSHRTHRBALDH1A1 | |
| SCHEMBL6131172 | 0.81 | TSHR (0.47) | TSHRTHRBALDH1A1 | |
| SCHEMBL1415511 | 0.78 | TSHR (0.47) | TSHRTHRBALDH1A1 | |
| SCHEMBL8886282 | 0.77 | TSHR (0.53) | TSHRTHRBALDH1A1 | |
| SCHEMBL28557383 | 0.77 | TSHR (0.46) | TSHRTHRBALDH1A1 | |
| SCHEMBL21295949 | 0.75 | TSHR (0.45) | TSHRTHRBALDH1A1 | |
| SCHEMBL31553186 | 0.73 | THRB (0.48) | TSHRTHRBALDH1A1 | |
| Perflexane SCHEMBL28384308 | 0.73 | THRB (0.48) | TSHRTHRBALDH1A1 | |
| SCHEMBL712225 | 0.72 | TSHR (0.45) | TSHRTHRBALDH1A1 | |
| SCHEMBL711741 | 0.72 | TSHR (0.45) | TSHRTHRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8337822-B2 | Treatment of the hair; forms a coating resistant to external attacks such as blow drying and/or perspiration, has excellent adhesion to individual hairs, and is resistant to shampooing; polyureadimethicone for example | L'OREAL (FR) | 2012-12-25 | — | — | US | disclosed |
| US-7799093-B2 | Coloring composition of keratinous fibers comprising at least one polysiloxane/polyurea block copolymer | L'ORéAL S.A. (FR) | 2010-09-21 | — | — | US | disclosed |
| US-20090053159-A1 | Anhydrous cosmetic compositions comprising at least one silicone copolymer, at least one volatile silicone, and at least one non-volatile linear polydimethylsiloxane | L'OREAL S.A. (FR) | 2009-02-26 | — | — | US | disclosed |
| US-20080171010-A1 | Use of a polysiloxane/polyurea block copolymer for the treatment of keratinous fibers | L'OREAL S.A. (FR) | 2008-07-17 | — | — | US | disclosed |
| US-20080127429-A1 | Coloring composition of keratinous fibers comprising at least one polysiloxane/polyurea block copolymer | L'OREAL S.A. (FR) | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171010-A1 | Use of a polysiloxane/polyurea block copolymer for the treatment of keratinous fibers | KRT18, POLR1C, PRKDC | TSHR 1783/4885THRB 802/4885ALDH1A1 4048/4885 |
| US-20080127429-A1 | Coloring composition of keratinous fibers comprising at least one polysiloxane/polyurea block copolymer | KRT18, PUF60, VIM | TSHR 4756/4885THRB 2875/4885ALDH1A1 2435/4885 |
| US-20090053159-A1 | Anhydrous cosmetic compositions comprising at least one silicone copolymer, at least one volatile silicone, and at least one non-volatile linear polydimethylsiloxane | KRT18, SHH, SPTAN1 | TSHR 1648/4885THRB 1618/4885ALDH1A1 2290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.