Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.45 |
| ▸ | GPR6 | P46095 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989849 | 0.79 | HSD17B13 (0.46) | GPR6LMNAALDH1A1L3MBTL1GAA | |
| SCHEMBL30989921 | 0.78 | RIPK1 (0.45) | RIPK1GPR6ALDH1A1L3MBTL1GAA | |
| SCHEMBL30989936 | 0.76 | RIPK1 (0.47) | RIPK1GPR6ALDH1A1L3MBTL1GAA | |
| SCHEMBL30989976 | 0.76 | RIPK1 (0.46) | RIPK1GPR6ALDH1A1L3MBTL1GAA | |
| SCHEMBL30989901 | 0.75 | RIPK1 (0.46) | RIPK1GPR6ALDH1A1L3MBTL1GAA | |
| SCHEMBL5644735 | 0.71 | RIPK1 (0.54) | RIPK1ALDH1A1GAAP2RX7MAOB | |
| SCHEMBL30989925 | 0.69 | RIPK1 (0.42) | RIPK1GPR6L3MBTL1HTT | |
| SCHEMBL5644473 | 0.69 | RIPK1 (0.51) | RIPK1LMNAALDH1A1GAAHTT | |
| SCHEMBL5647030 | 0.68 | KMT2A (0.58) | RIPK1 | |
| SCHEMBL3964632 | 0.68 | RIPK1 (0.59) | RIPK1ALDH1A1HTTKDM4EMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |