Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.43 |
| ▸ | GPR6 | P46095 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989936 | 0.91 | RIPK1 (0.47) | RIPK1PIK3C3GPR6GAANPC1 | |
| SCHEMBL30989921 | 0.88 | RIPK1 (0.45) | RIPK1PIK3C3GPR6GAAKDM4E | |
| SCHEMBL30989976 | 0.81 | RIPK1 (0.46) | RIPK1GPR6GAANPC1KDM4E | |
| SCHEMBL30989882 | 0.80 | MEN1 (0.48) | RIPK1PIK3C3GAANPC1KDM4E | |
| SCHEMBL30989942 | 0.79 | RIPK1 (0.45) | RIPK1PIK3C3GPR6GAAMEN1 | |
| SCHEMBL30989827 | 0.78 | PIK3C3 (0.41) | RIPK1PIK3C3GPR6GAANPC1 | |
| SCHEMBL30989925 | 0.77 | RIPK1 (0.42) | RIPK1GPR6L3MBTL1PTGER4 | |
| SCHEMBL30989755 | 0.76 | GAA (0.48) | PIK3C3GAAMEN1KMT2AMAPT | |
| SCHEMBL30989781 | 0.76 | RIPK1 (0.46) | RIPK1PIK3C3GAANPC1ALDH1A1 | |
| SCHEMBL30989804 | 0.75 | RIPK1 (0.45) | RIPK1PIK3C3GPR6GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |