Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.43 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | GPR6 | P46095 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989936 | 0.90 | RIPK1 (0.47) | RIPK1PIK3C3GAAGPBAR1GPR6 | |
| SCHEMBL30989925 | 0.89 | RIPK1 (0.42) | RIPK1HAO1GPR6PTGER1NLRP3 | |
| SCHEMBL30989901 | 0.88 | RIPK1 (0.46) | RIPK1PIK3C3GAAGPR6KDM4E | |
| SCHEMBL30989755 | 0.88 | GAA (0.48) | PIK3C3HAO1GAAGPBAR1SCN9A | |
| SCHEMBL30989856 | 0.87 | GPR6 (0.40) | PIK3C3HAO1GAAGPBAR1GPR6 | |
| SCHEMBL30989973 | 0.84 | RIPK1 (0.44) | RIPK1GAAGPBAR1NLRP3ALDH1A1 | |
| SCHEMBL30989967 | 0.84 | RIPK1 (0.44) | RIPK1GAAGPBAR1NLRP3ALDH1A1 | |
| SCHEMBL30989909 | 0.83 | CLK1 (0.48) | RIPK1ALDH1A1 | |
| SCHEMBL30989786 | 0.82 | RXFP1 (0.45) | RIPK1PIK3C3GPBAR1ALDH1A1MAPT | |
| SCHEMBL30989886 | 0.82 | CLK1 (0.44) | RIPK1PIK3C3GAAGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |