Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GPR6 | P46095 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989901 | 0.91 | RIPK1 (0.46) | RIPK1PIK3C3GAAGPR6KDM4E | |
| SCHEMBL30989921 | 0.90 | RIPK1 (0.45) | RIPK1PIK3C3GAAGPR6KDM4E | |
| SCHEMBL30989882 | 0.88 | MEN1 (0.48) | RIPK1PIK3C3GAAKDM4EALDH1A1 | |
| SCHEMBL30989942 | 0.88 | RIPK1 (0.45) | RIPK1PIK3C3GAAGPR6L3MBTL1 | |
| SCHEMBL30989827 | 0.86 | PIK3C3 (0.41) | RIPK1PIK3C3GAAGPR6MAPT | |
| SCHEMBL30989781 | 0.84 | RIPK1 (0.46) | RIPK1PIK3C3GAAALDH1A1MAPT | |
| SCHEMBL30989900 | 0.82 | PIK3C3 (0.38) | RIPK1PIK3C3GAAGPR6MAPT | |
| SCHEMBL30989864 | 0.81 | CLK1 (0.51) | RIPK1GAAALDH1A1MEN1KMT2A | |
| SCHEMBL30989976 | 0.81 | RIPK1 (0.46) | RIPK1GAAGPR6KDM4EALDH1A1 | |
| SCHEMBL30989884 | 0.79 | NPC1 (0.46) | GAAGPR6KDM4EALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |