Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989882 | 0.86 | MEN1 (0.48) | NPC1RAB9AGAANLRP3MEN1 | |
| SCHEMBL30989781 | 0.82 | RIPK1 (0.46) | NPC1GAANLRP3MEN1KMT2A | |
| SCHEMBL30989869 | 0.81 | LRRK2 (0.37) | GAAGPR6GPBAR1 | |
| SCHEMBL30989880 | 0.81 | LRRK2 (0.37) | GAAGPR6GPBAR1 | |
| SCHEMBL30989856 | 0.81 | GPR6 (0.40) | NPC1RAB9AGAANLRP3GPR6 | |
| SCHEMBL30989911 | 0.80 | RIPK1 (0.46) | GAAGPR6ALDH1A1GRIN1GRIN2B | |
| SCHEMBL30989936 | 0.79 | RIPK1 (0.47) | NPC1GAAMEN1KMT2AGPR6 | |
| SCHEMBL30989827 | 0.78 | PIK3C3 (0.41) | NPC1GAAMEN1KMT2AGPR6 | |
| SCHEMBL30989864 | 0.77 | CLK1 (0.51) | GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL30989737 | 0.72 | PIK3C3 (0.37) | GPR6GPBAR1JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |