Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | GPR6 | P46095 | 7/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989880 | 1.00 | LRRK2 (0.37) | LRRK2GPR6PIK3C3RIPK1MAPT | |
| SCHEMBL30989900 | 0.84 | PIK3C3 (0.38) | GPR6PIK3C3RIPK1MAPTGPBAR1 | |
| SCHEMBL30989884 | 0.81 | NPC1 (0.46) | GPR6GPBAR1GAA | |
| SCHEMBL30989936 | 0.77 | RIPK1 (0.47) | GPR6PIK3C3RIPK1MAPTGPBAR1 | |
| SCHEMBL30989882 | 0.75 | MEN1 (0.48) | PIK3C3RIPK1MAPTPDE4APDE4B | |
| SCHEMBL30989856 | 0.75 | GPR6 (0.40) | LRRK2GPR6PIK3C3GPBAR1GAA | |
| SCHEMBL30989781 | 0.73 | RIPK1 (0.46) | PIK3C3RIPK1MAPTGPBAR1PDE4A | |
| SCHEMBL30989864 | 0.73 | CLK1 (0.51) | RIPK1GAA | |
| SCHEMBL30989737 | 0.72 | PIK3C3 (0.37) | LRRK2GPR6PIK3C3RIPK1GPBAR1 | |
| SCHEMBL30989827 | 0.71 | PIK3C3 (0.41) | GPR6PIK3C3RIPK1MAPTGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |