Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989882 | 0.91 | MEN1 (0.48) | RIPK1MAPTNPC1KMT2AMEN1 | |
| SCHEMBL30989973 | 0.89 | RIPK1 (0.44) | RIPK1MAPTNPC1KMT2AMEN1 | |
| SCHEMBL30989967 | 0.89 | RIPK1 (0.44) | RIPK1MAPTNPC1KMT2AMEN1 | |
| SCHEMBL30989870 | 0.88 | RIPK1 (0.43) | RIPK1MAPTNPC1KMT2AMEN1 | |
| SCHEMBL30989876 | 0.85 | RIPK1 (0.48) | RIPK1NPC1KMT2AMEN1ATM | |
| SCHEMBL30989936 | 0.84 | RIPK1 (0.47) | RIPK1MAPTNPC1KMT2AMEN1 | |
| SCHEMBL30989864 | 0.82 | CLK1 (0.51) | RIPK1KMT2AMEN1GAAALDH1A1 | |
| SCHEMBL30989884 | 0.82 | NPC1 (0.46) | NPC1KMT2AMEN1GAANLRP3 | |
| SCHEMBL30989827 | 0.80 | PIK3C3 (0.41) | RIPK1MAPTNPC1KMT2AMEN1 | |
| SCHEMBL30989944 | 0.79 | MET (0.52) | RIPK1MAPTKMT2AMEN1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |