Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989781 | 0.91 | RIPK1 (0.46) | MEN1KMT2AATMRIPK1NPC1 | |
| SCHEMBL30989936 | 0.88 | RIPK1 (0.47) | MEN1KMT2ARIPK1NPC1MAPT | |
| SCHEMBL30989884 | 0.86 | NPC1 (0.46) | MEN1KMT2ANPC1KDM4EALDH1A1 | |
| SCHEMBL30989827 | 0.82 | PIK3C3 (0.41) | MEN1KMT2ARIPK1NPC1MAPT | |
| SCHEMBL30989864 | 0.81 | CLK1 (0.51) | MEN1KMT2ARIPK1ALDH1A1GAA | |
| SCHEMBL30989967 | 0.80 | RIPK1 (0.44) | MEN1KMT2AATMRIPK1NPC1 | |
| SCHEMBL30989973 | 0.80 | RIPK1 (0.44) | MEN1KMT2AATMRIPK1NPC1 | |
| SCHEMBL30989901 | 0.80 | RIPK1 (0.46) | MEN1KMT2ARIPK1NPC1MAPT | |
| SCHEMBL30989870 | 0.79 | RIPK1 (0.43) | MEN1KMT2AATMRIPK1NPC1 | |
| SCHEMBL30990019 | 0.78 | LMNA (0.57) | MEN1KMT2AMAPTALDH1A1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |