Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.51 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989909 | 0.90 | CLK1 (0.48) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL30989972 | 0.88 | ALDH1A1 (0.49) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL30989781 | 0.82 | RIPK1 (0.46) | RIPK1HPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL30989882 | 0.81 | MEN1 (0.48) | RIPK1ALDH1A1KMT2AMEN1GAA | |
| SCHEMBL30989936 | 0.81 | RIPK1 (0.47) | RIPK1ALDH1A1KMT2AMEN1GAA | |
| SCHEMBL30989827 | 0.80 | PIK3C3 (0.41) | RIPK1KMT2AMEN1POLBGAA | |
| SCHEMBL30989923 | 0.78 | ALDH1A1 (0.47) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL30989886 | 0.78 | CLK1 (0.44) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL30989930 | 0.76 | HSP90AA1 (0.52) | DYRK1AHPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL30989873 | 0.76 | MAPK1 (0.41) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |