Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.44 |
| ▸ | CLK2 | P49760 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989813 | 0.95 | CLK1 (0.43) | CLK1CLK2DYRK1AHSP90AA1GPBAR1 | |
| SCHEMBL30989909 | 0.89 | CLK1 (0.48) | CLK1CLK2DYRK1AHSP90AA1POLB | |
| SCHEMBL30989808 | 0.87 | HTT (0.39) | CLK1CLK2DYRK1AHSP90AA1TACR1 | |
| SCHEMBL30989930 | 0.84 | HSP90AA1 (0.52) | DYRK1AHSP90AA1GAAHPGD | |
| SCHEMBL30989793 | 0.83 | HTT (0.38) | CLK1CLK2DYRK1AHSP90AA1GPBAR1 | |
| SCHEMBL30989921 | 0.82 | RIPK1 (0.45) | GPBAR1RIPK1PIK3C3GAA | |
| SCHEMBL30989912 | 0.82 | HTT (0.37) | CLK1CLK2DYRK1AHSP90AA1TACR1 | |
| SCHEMBL30989786 | 0.81 | RXFP1 (0.45) | GPBAR1POLBPTGER4PTGER2RIPK1 | |
| SCHEMBL30989898 | 0.81 | GPBAR1 (0.42) | HSP90AA1GPBAR1POLBFFAR4PIK3C3 | |
| SCHEMBL30989848 | 0.79 | MAPT (0.43) | HSP90AA1GPBAR1TACR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |