Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LIPE | Q05469 | 2/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25228040 | 0.82 | GPBAR1 (0.43) | GPBAR1PIK3C3FFAR4TSHRLIPE | |
| SCHEMBL30989930 | 0.82 | HSP90AA1 (0.52) | GAAMEN1KMT2AALDH1A1HSP90AA1 | |
| SCHEMBL30989886 | 0.81 | CLK1 (0.44) | GPBAR1PIK3C3FFAR4GAAPOLB | |
| SCHEMBL30989848 | 0.81 | MAPT (0.43) | GPBAR1LIPEMEN1KMT2AMAPK1 | |
| SCHEMBL30989813 | 0.79 | CLK1 (0.43) | GPBAR1PIK3C3FFAR4POLBHSP90AA1 | |
| SCHEMBL30989786 | 0.79 | RXFP1 (0.45) | GPBAR1PIK3C3MEN1KMT2AMCOLN3 | |
| SCHEMBL30989921 | 0.77 | RIPK1 (0.45) | GPBAR1PIK3C3GAAALDH1A1MAPT | |
| SCHEMBL30989909 | 0.77 | CLK1 (0.48) | MEN1KMT2AMAPK1ALDH1A1POLB | |
| SCHEMBL9653496 | 0.77 | KDM4E (0.45) | GPBAR1FFAR4TSHRLIPEMEN1 | |
| SCHEMBL9656790 | 0.77 | FFAR4 (0.43) | GPBAR1FFAR4TSHRLIPEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |