Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.48 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989864 | 0.90 | CLK1 (0.51) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL30989886 | 0.89 | CLK1 (0.44) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL30989923 | 0.89 | ALDH1A1 (0.47) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL30989930 | 0.88 | HSP90AA1 (0.52) | DYRK1AHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL30989832 | 0.87 | TSPO (0.43) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL30989813 | 0.87 | CLK1 (0.43) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL30989786 | 0.84 | RXFP1 (0.45) | RIPK1ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL30989921 | 0.83 | RIPK1 (0.45) | RIPK1ALDH1A1 | |
| SCHEMBL30989848 | 0.82 | MAPT (0.43) | ALDH1A1MEN1KMT2AHSP90AA1POLB | |
| SCHEMBL30989967 | 0.82 | RIPK1 (0.44) | RIPK1ALDH1A1MEN1KMT2AHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |