Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989786 | 0.88 | RXFP1 (0.45) | MAPTRXFP1GPBAR1MEN1KMT2A | |
| SCHEMBL30989930 | 0.84 | HSP90AA1 (0.52) | RXFP1HSP90AA1MEN1KMT2AALDH1A1 | |
| SCHEMBL30989909 | 0.82 | CLK1 (0.48) | HSP90AA1MEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL30989973 | 0.81 | RIPK1 (0.44) | MAPTRXFP1HSP90AA1GPBAR1MEN1 | |
| SCHEMBL30989967 | 0.81 | RIPK1 (0.44) | MAPTRXFP1HSP90AA1GPBAR1MEN1 | |
| SCHEMBL30989898 | 0.81 | GPBAR1 (0.42) | MAPTHSP90AA1GPBAR1LIPEMEN1 | |
| SCHEMBL30989921 | 0.80 | RIPK1 (0.45) | MAPTGPBAR1ALDH1A1 | |
| SCHEMBL30989886 | 0.79 | CLK1 (0.44) | HSP90AA1GPBAR1TACR1POLB | |
| SCHEMBL30989813 | 0.77 | CLK1 (0.43) | HSP90AA1GPBAR1TACR1POLB | |
| SCHEMBL25228040 | 0.75 | GPBAR1 (0.43) | GPBAR1LIPEMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |